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Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat.
BACKGROUND & AIMS In this study, we investigated the role of leptin and its receptors (Ob-R) in profibrogenic responses in the liver using Zucker (fa/fa) rats, a natural occurring Ob-R-deficientExpand
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Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling.
Although bacterial endotoxin, such as lipopolysaccharide (LPS), plays a key role in the pathogenesis of nonalcoholic steatohepatitis (NASH), detailed mechanisms of this pathogenesis remain unclear.Expand
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Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin.
BACKGROUND & AIMS Ethanol causes both tolerance and sensitization of Kupffer cells. This study was designed to evaluate temporal effects of ethanol in an attempt to understand this paradox. METHODSExpand
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Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin.
The relationship among gender, lipopolysaccharide (LPS), and liver disease is complex. Accordingly, the effect of estrogen on activation of Kupffer cells by endotoxin was studied. All rats givenExpand
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Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals
Lines of evidence suggested a possible link between leptin and hepatic fibrosis; however, whether leptin modulates the fibrogenesis in the liver remains unclear. The purpose of this study, therefore,Expand
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Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in industrialized countries worldwide, and has become a serious public health issue not only inExpand
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Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease
Chronic cholestasis often results in premature death from liver failure with fibrosis; however, the molecular mechanisms contributing to biliary cirrhosis are not demonstrated. In this article, weExpand
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Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver
In this study, we investigated hepatic fibrogenesis caused by long‐term thioacetamide (TAA) administration in ob/ob mice, a naturally occurring leptin deficient animal. In the lean littermates,Expand
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Dietary glycine prevents chemical-induced experimental colitis in the rat.
BACKGROUND & AIMS In this study, the effect of dietary glycine on experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid (TNBS) and dextran sulfate sodium (DSS) in the rat wasExpand
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Role of Kupffer cells and gut‐derived endotoxins in alcoholic liver injury1
The hepatotoxic effects of alcohol have been described in detail, but factors responsible for its hepatotoxicity have only partially been characterized. For example, it is known that chronic ethanolExpand
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