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Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat.
BACKGROUND & AIMS In this study, we investigated the role of leptin and its receptors (Ob-R) in profibrogenic responses in the liver using Zucker (fa/fa) rats, a natural occurring Ob-R-deficient… Expand
Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling.
Although bacterial endotoxin, such as lipopolysaccharide (LPS), plays a key role in the pathogenesis of nonalcoholic steatohepatitis (NASH), detailed mechanisms of this pathogenesis remain unclear.… Expand
Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin.
BACKGROUND & AIMS Ethanol causes both tolerance and sensitization of Kupffer cells. This study was designed to evaluate temporal effects of ethanol in an attempt to understand this paradox. METHODS… Expand
Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin.
- K. Ikejima, N. Enomoto, +6 authors R. Thurman
- Medicine, Biology
- American journal of physiology. Gastrointestinal…
- 1 April 1998
The relationship among gender, lipopolysaccharide (LPS), and liver disease is complex. Accordingly, the effect of estrogen on activation of Kupffer cells by endotoxin was studied. All rats given… Expand
Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals
Lines of evidence suggested a possible link between leptin and hepatic fibrosis; however, whether leptin modulates the fibrogenesis in the liver remains unclear. The purpose of this study, therefore,… Expand
Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
- S. Watanabe, E. Hashimoto, +17 authors T. Shimosegawa
- Journal of Gastroenterology
- 24 February 2015
Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in industrialized countries worldwide, and has become a serious public health issue not only in… Expand
Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease
- K. Takeda, Y. Kojima, +14 authors K. Okumura
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 5 August 2008
Chronic cholestasis often results in premature death from liver failure with fibrosis; however, the molecular mechanisms contributing to biliary cirrhosis are not demonstrated. In this article, we… Expand
Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver
In this study, we investigated hepatic fibrogenesis caused by long‐term thioacetamide (TAA) administration in ob/ob mice, a naturally occurring leptin deficient animal. In the lean littermates,… Expand
Dietary glycine prevents chemical-induced experimental colitis in the rat.
BACKGROUND & AIMS In this study, the effect of dietary glycine on experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid (TNBS) and dextran sulfate sodium (DSS) in the rat was… Expand
Role of Kupffer cells and gut‐derived endotoxins in alcoholic liver injury1
- N. Enomoto, K. Ikejima, +14 authors R. Thurman
- Journal of gastroenterology and hepatology
- 1 March 2000
The hepatotoxic effects of alcohol have been described in detail, but factors responsible for its hepatotoxicity have only partially been characterized. For example, it is known that chronic ethanol… Expand