• Publications
  • Influence
Toll‐like receptor 4 is involved in the mechanism of early alcohol‐induced liver injury in mice
D Dietary alcohol significantly increased liver‐to‐body weight ratios and serum alanine transaminase (ALT) levels in wild‐type mice over high‐fat controls, which is consistent with the hypothesis that Kupffer cell activation by endotoxin via TLR4 is involved in early alcohol‐induced liver injury.
NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.
The hypothesis that free radicals from NADPH oxidase in hepatic Kupffer cells play a predominant role in the pathogenesis of early alcohol-induced hepatitis by activating NF-kappaB, which activates production of cytotoxic TNF-alpha is strongly supported.
II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin.
  • R. Thurman
  • Medicine, Biology
    American journal of physiology. Gastrointestinal…
  • 1 October 1998
The hypothesis that alcohol-induced liver injury involves increases in circulating endotoxin, leading to activation of Kupffer cells, which causes a hypoxia-reoxygenation injury is proposed.
Reperfusion injury after liver preservation for transplantation.
Understanding of the roles of different cells in storage/reperfusion injury forms the basis for strategies to prolong organ storage, improve graft function, and reduce failure of fatty grafts from alcoholic donors.
Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin.
Estrogen treatment in vivo sensitizes Kupffer cells to LPS, leading to increased toxic mediator production by the liver, and estrogen treatment increased LPS binding protein mRNA dramatically in liver in 6-24 h.
Antibodies to tumor necrosis factor alpha prevent increases in cell replication in liver due to the potent peroxisome proliferator, WY-14,643.
It is demonstrated that neutralizing antibodies to tumor necrosis factor alpha (TNF alpha) block increases in protein kinase C and cell proliferation due to [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (WY-14,643), a hypolipidemic drug and potent peroxisome proliferator that causes tumors.
The role of Kupffer cell oxidant production in early ethanol-induced liver disease.