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INSR gene

Known as: INSR, CD220, INSULIN RECEPTOR 
This gene is involved in glucose uptake regulation.
National Institutes of Health

Related topics

Related topics

9 relations
Carbohydrate MetabolismDiabetes MellitusINSR protein, humanINSR wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression.
Highly Cited
2004
Highly Cited
2004
Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR.
The insulin receptor (IR) lacking the alternatively spliced exon 11 (IR-A) is preferentially expressed in fetal and cancer cells… 
Highly Cited
2000
Highly Cited
2000
Genetic modifiers of the insulin resistance phenotype in mice.
Insulin resistance can result from genetic interactions among susceptibility alleles. To identify genetic loci predisposing to… 
Highly Cited
1995
Highly Cited
1995
The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.
We report the cloning and primary structure of the Drosophila insulin receptor gene (inr), functional expression of the predicted… 
Highly Cited
1995
Highly Cited
1995
Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.
To identify potential signaling molecules involved in mediating insulin-induced biological responses, a yeast two-hybrid screen… 
Highly Cited
1993
Highly Cited
1993
Ligand-binding properties of the two isoforms of the human insulin receptor.
Tissue-specific alternative splicing of exon 11 of the insulin receptor gene results in 2 mRNAs that differ by 36 nucleotides… 
Highly Cited
1990
Highly Cited
1990
Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance.
The nucleotide sequence was determined for all 22 exons of the insulin receptor gene from three patients with genetic syndromes… 
Highly Cited
1989
Highly Cited
1989
Structure of the human insulin receptor gene and characterization of its promoter.
The human insulin receptor gene, INSR, and its promoter region have been isolated and characterized. The gene spans greater than… 
Highly Cited
1988
Highly Cited
1988
Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing.
A point mutation in the human insulin receptor gene in a patient with type A insulin resistance alters the amino acid sequence… 
Highly Cited
1988
Highly Cited
1988
Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.
Insulin receptor complementary DNA has been cloned from an insulin-resistant patient with leprechaunism whose receptors exhibited… 
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