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INSR protein, human

Known as: INSR, insulin receptor, human, IR 
Insulin receptor (1382 aa, ~156 kDa) is encoded by the human INSR gene. This protein plays a role in both signal transduction and glucose homeostasis… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
We examined the effects of an inhibitor of PI3K, XL147, against human breast cancer cell lines with constitutive PI3K activation… Expand
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Highly Cited
2010
Highly Cited
2010
SUMMARY In Senegalese sole (Solea senegalensis Kaup), growth is negatively correlated to dietary lipid levels. To understand the… Expand
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Highly Cited
2008
Highly Cited
2008
BACKGROUND & AIMS Maintaining the integrity of networks of interstitial cells of Cajal (ICC) is essential to preserve orderly… Expand
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Highly Cited
2007
Highly Cited
2007
Insulin and insulin-like growth factor 1 (IGF1) are ubiquitous growth factors that regulate proliferation in most mammalian… Expand
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Highly Cited
2007
Highly Cited
2007
Male prairie voles (Microtus ochrogaster) display mating-induced pair bonding indicated by social affiliation with their female… Expand
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Highly Cited
2004
Highly Cited
2004
IGF-IR-mediated signaling promotes survival, anchorage-independent growth, and oncogenic transformation, as well as tumor growth… Expand
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Review
2001
Review
2001
The IGF system components have been implicated in breast cancer progression. IGF-I and IGF-II are mitogenic and anti-apoptotic… Expand
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Highly Cited
1998
Highly Cited
1998
Abstract The formation of foam cells from macrophages in the arterial wall is characterized by dramatic changes in lipid… Expand
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Highly Cited
1996
Highly Cited
1996
Targeted disruption of the insulin receptor gene (Insr) in the mouse was achieved using the homologous recombination approach… Expand
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Highly Cited
1983
Highly Cited
1983
Preparations of insulin receptor from cultured 3T3-L1 adipocytes and human placenta previously was found to catalyze the… Expand
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