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A Family of Sulfonylurea Receptors Determines the Pharmacological Properties of ATP-Sensitive K+ Channels
We have cloned an isoform of the sulfonylurea receptor (SUR), designated SUR2. Coexpression of SUR2 and the inward rectifier K+ channel subunit Kir6.2 in COS1 cells reconstitutes the properties of… Expand
PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis.
Stimulus-secretion coupling is an essential process in secretory cells in which regulated exocytosis occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While an increase in… Expand
cAMP-GEFII is a direct target of cAMP in regulated exocytosis
Although cAMP is well known to regulate exocytosis in many secretory cells, its direct target in the exocytotic machinery is not known. Here we show that cAMP-GEFII, a cAMP sensor, binds to Rim… Expand
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
- T. Shibasaki, H. Takahashi, +8 authors S. Seino
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 4 December 2007
cAMP is well known to regulate exocytosis in various secretory cells, but the precise mechanism of its action remains unknown. Here, we examine the role of cAMP signaling in the exocytotic process of… Expand
ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis
Glucose-responsive (GR) neurons in the hypothalamus are thought to be critical in glucose homeostasis, but it is not known how they function in this context. Kir6.2 is the pore-forming subunit of… Expand
Physiological and pathophysiological roles of ATP-sensitive K+ channels.
ATP-sensitive potassium (K(ATP)) channels are present in many tissues, including pancreatic islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple the cell… Expand
GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
Glucagon-like peptide-1 receptor (GLP-1R) agonists exert antihypertensive actions through incompletely understood mechanisms. Here we demonstrate that cardiac Glp1r expression is localized to cardiac… Expand
PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue.
Adipose tissue secretes adipokines that mediate insulin resistance, a characteristic feature of obesity and type 2 diabetes. By differential proteome analysis of cellular models of insulin… Expand
The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs
Expanding Sulfonylurea Mechanisms Sulfonylureas are important drugs used for treatment of diabetes that act through adenosine triphosphate–sensitive potassium channels to promote secretion of insulin… Expand
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem
Voltage-dependent calcium (Ca2+) channels are involved in many specialized cellular functions, and are controlled by intracellular signals such as heterotrimeric G-proteins, protein kinases and… Expand