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IL28B protein, human

Known as: Interleukin-28C, Interferon Lambda 3, IL-28B protein, human 
Interferon lambda-3 (196 aa, ~22 kDa) is encoded by the human IFNL3 gene. This protein plays a role in cytokine signaling.
National Institutes of Health

Related topics

Related topics

8 relations
Antiviral ResponseCytokine GeneCytokine Receptor BindingCytokine Signaling

Broader (1)

Interleukins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Re-treatment of Chronic Hepatitis C Virus Genotype 1 Infection After Relapse
Context The treatment of hepatitis C virus is changing rapidly with the introduction of interferon-free regimens that include… 
Review
2014
Review
2014
Sofosbuvir-Based Treatment Regimens for Chronic, Genotype 1 Hepatitis C Virus Infection in U.S. Incarcerated Populations
Context Despite high prevalence of chronic hepatitis C virus (HCV) infection among incarcerated persons, prisons offer a low… 
Highly Cited
2014
Highly Cited
2014
IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza
Influenza is a major cause of morbidity and mortality in immunosuppressed persons, and vaccination often confers insufficient… 
Highly Cited
2013
Highly Cited
2013
Genome-Wide Association Study of Spontaneous Resolution of Hepatitis C Virus Infection: Data From Multiple Cohorts
UNLABELLED Chinese translation BACKGROUND Hepatitis C virus (HCV) infections occur worldwide and either spontaneously resolve… 
Highly Cited
2012
Highly Cited
2012
New Protease Inhibitors for the Treatment of Chronic Hepatitis C
BACKGROUND Chronic hepatitis C virus is difficult to treat and affects approximately 3 million Americans. Protease inhibitors… 
Highly Cited
2011
Highly Cited
2011
Interleukin‐28B polymorphisms are associated with histological recurrence and treatment response following liver transplantation in patients with hepatitis C virus infection
Polymorphism in the interleukin‐28B (IL28B) gene region, encoding interferon (IFN)‐λ3, is strongly predictive of response to… 
Highly Cited
2011
Highly Cited
2011
Genetic variation in the interleukin‐28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection
Polymorphisms in the interleukin‐28B (IL28B) region are associated with spontaneous and treatment‐induced viral clearance in… 
2011
2011
Interleukin‐28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV‐1‐infected cohort
Summary.  Twenty‐five per cent of individuals infected with hepatitis C virus (HCV) are able to clear HCV spontaneously… 
Highly Cited
2010
Highly Cited
2010
Interleukin‐28B genetic variants and hepatitis virus infection by different viral genotypes
Genetic host factors may modify the course of the hepatitis C virus (HCV) infection. Very recently, a genome‐wide scan that… 
Highly Cited
2009
Highly Cited
2009
Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity.
Improving the potency of immune responses is paramount among issues concerning vaccines against deadly pathogens. IL-28B belongs… 
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