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IL28B protein, human

Known as: Interleukin-28C, Interferon Lambda 3, IL-28B protein, human 
Interferon lambda-3 (196 aa, ~22 kDa) is encoded by the human IFNL3 gene. This protein plays a role in cytokine signaling.
National Institutes of Health

Related topics

Related topics

8 relations
Antiviral ResponseCytokine GeneCytokine Receptor BindingCytokine Signaling

Broader (1)

Interleukins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Spontaneous Viral Load Decline and Subsequent Clearance of Chronic Hepatitis C Virus in Postpartum Women Correlates With Favorable Interleukin-28B Gene Allele
Background Postpartum hepatitis C viral (HCV) load decline followed by spontaneous clearance has been previously described… 
2015
2015
Hepatic expression levels of interferons and interferon-stimulated genes in patients with chronic hepatitis C: A phenotype–genotype correlation study
IFNL4 is linked to hepatitis C virus treatment response and type III interferons (IFNs). We studied the functional associations… 
2014
2014
IFNL3 (IL28B) and IFNL4 polymorphisms are associated with treatment response in Thai patients infected with HCV genotype 1, but not with genotypes 3 and 6
Recent studies have shown an association between single nucleotide polymorphisms (SNPs) in the interferon lambda‐3 (IFNL3 or IL… 
2014
2014
IFNL3 (IL28B) polymorphism does not predict long‐term response to interferon therapy in HBeAg‐positive chronic hepatitis B patients
The impact of IFNL3 (IL28B) polymorphism on response to interferon (IFN) treatment in patients infected with hepatitis B virus… 
Review
2013
Review
2013
Role of Interleukin-28B Polymorphism as a Predictor of Sustained Virological Response in Patients with Chronic Hepatitis C Treated with Triple Therapy: A Systematic Review and Meta-Analysis
Background and ObjectiveChronic hepatitis C represents an important health problem. The aim of our meta-analysis was to establish… 
2013
2013
CC genotype donors for the interleukin‐28B single nucleotide polymorphism are associated with better outcomes in hepatitis C after liver transplant
Interleukin‐28B (IL‐28B) polymorphism is the strongest pretreatment predictor of viral clearance in the hepatitis C (HCV… 
2012
2012
Association of two polymorphisms of the IL28B gene with viral factors and treatment response in 1,518 patients infected with hepatitis C virus
BackgroundTwo nucleotide polymorphisms of the interleukin-28B (IL28B) gene, at rs8099917 and rs12979860, influence the response… 
Highly Cited
2012
Highly Cited
2012
Polymorphisms in interleukin‐10 and interleukin‐28B genes in Egyptian patients with chronic hepatitis C virus genotype 4 and their effect on the response to pegylated interferon/ribavirin‐therapy
Recently, it has been suggested that single nucleotide polymorphisms (SNPs) in some cytokine genes may influence the production… 
2011
2011
Genetic Variation of the IL-28B Promoter Affecting Gene Expression
The current standard of care for the treatment of chronic hepatitis C is pegylated interferon-α (PEG-IFNα) and ribavirin (RBV… 
2011
2011
Simple assay based on restriction fragment length polymorphism associated with IL28B in chronic hepatitis C patients
Abstract Objective. Several studies recently revealed that single nucleotide polymorphisms (SNPs) in the interleukin28B (IL28B… 
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