IFNL3 (IL28B) and IFNL4 polymorphisms are associated with treatment response in Thai patients infected with HCV genotype 1, but not with genotypes 3 and 6.

@article{Akkarathamrongsin2014IFNL3A,
  title={IFNL3 (IL28B) and IFNL4 polymorphisms are associated with treatment response in Thai patients infected with HCV genotype 1, but not with genotypes 3 and 6.},
  author={Srunthron Akkarathamrongsin and Vo Duy Thong and Sunchai Payungporn and Kittiyod Poovorawan and Phisit Prapunwattana and Yong Poovorawan and Pisit Tangkijvanich},
  journal={Journal of medical virology},
  year={2014},
  volume={86 9},
  pages={
          1482-90
        }
}
Recent studies have shown an association between single nucleotide polymorphisms (SNPs) in the interferon lambda-3 (IFNL3 or IL-28B) and IFNL4 genes and treatment response to hepatitis C virus genotype 1 (HCV-1) infection. The importance of these SNPs for HCV genotype 3 (HCV-3), and particularly HCV genotype 6 (HCV-6), remains to be elucidated. We analyzed a cohort of 225 Thai individuals with chronic HCV infection treated with pegylated-interferon and ribavirin, of whom 69 (30.7%), 114 (50.7… CONTINUE READING
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