• Publications
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Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
Hepatitis C virus (HCV) infection causes chronic liver diseases and is a global public health problem. Detailed analyses of HCV have been hampered by the lack of viral culture systems. SubgenomicExpand
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Management of hepatitis B: Summary of a clinical research workshop
Chronic hepatitis B is caused by persistent infection with the hepatitis B virus (HBV), a unique DNA virus that replicates through an RNA intermediate produced from a stable covalently closedExpand
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Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C
Dr. T. Jake Liang (Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases [NIDDK], National Institutes of Health [NIH], Bethesda, Maryland): The identification ofExpand
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A genome-wide genetic screen for host factors required for hepatitis C virus propagation
  • Q. Li, A. Brass, +4 authors S. Elledge
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 22 September 2009
Hepatitis C virus (HCV) infection is a major cause of end-stage liver disease and a leading indication for liver transplantation. Current therapy fails in many instances and is associated withExpand
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HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons.
BACKGROUND & AIMS Polymorphisms in the IL28B gene have been associated with clearance of hepatitis C virus (HCV), indicating a role for type III interferons (IFNs) in HCV infection. Little is knownExpand
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Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA
Clearance of Chronic Virus The family of mRNA-editing enzymes, APOBEC, restricts hepatitis B virus (HBV) replication. Lucifora et al. (p. 1221, published online 20 February; see the Perspective byExpand
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Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated withExpand
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Impaired Effector Function of Hepatitis C Virus-Specific CD8+ T Cells in Chronic Hepatitis C Virus Infection1
The cellular immune response contributes to clearance of hepatitis C virus (HCV) and persists for decades after recovery from infection. The immunological basis for the inefficiency of the cellularExpand
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Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection
The function of the hepatitis B e antigen (HBeAg) is largely unknown because it is not required for viral assembly, replication, or infection. In this report we chronicle clinical and experimentalExpand
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Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection.
BACKGROUND & AIMS Chronic infection with hepatitis B or C virus (HBV or HCV) is a leading cause of cirrhosis by unknown mechanisms of pathogenesis. Translocation of gut microbial products into theExpand
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