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Hydro-Lyases

Known as: hydrase, hydro lyase, Dehydratases 
Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.
National Institutes of Health

Related topics

Related topics

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Narrower (46)

(R)-2-methylmalate dehydratase(S)-2-methylmalate dehydratase2,2-dimethylcyclopropanecarbonitrile hydratase, Rhodococcus boritolerans2-hydroxypentadienoic acid hydratase
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In BloodProcess of secretionantagonists & inhibitorschemical synthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity
Excess copper is poisonous to all forms of life, and copper overloading is responsible for several human pathologic processes… 
Highly Cited
2007
Highly Cited
2007
Micromolar Intracellular Hydrogen Peroxide Disrupts Metabolism by Damaging Iron-Sulfur Enzymes*
An Escherichia coli strain that cannot scavenge hydrogen peroxide has been used to identify the cell processes that are most… 
Highly Cited
1999
Highly Cited
1999
A Developmentally Regulated Gene Cluster Involved in Conidial Pigment Biosynthesis in Aspergillus fumigatus
ABSTRACT Aspergillus fumigatus, a filamentous fungus producing bluish-green conidia, is an important opportunistic pathogen that… 
Highly Cited
1996
Highly Cited
1996
Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase.
Review
1995
Review
1995
Superoxide radical and superoxide dismutases.
  • I. Fridovich
  • Annual review of biochemistry
  • 1995
  • Corpus ID: 26834871
O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then… 
Highly Cited
1994
Highly Cited
1994
The role of O2.- in the production of HO.: in vitro and in vivo.
Highly Cited
1976
Highly Cited
1976
Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.
Review
1973
Review
1973
Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.
  • F. Oesch
  • Xenobiotica; the fate of foreign compounds in…
  • 1973
  • Corpus ID: 32500968
Abstract1. Several aromatic and olefinic compounds are converted to intermediate arene and alkene oxides by mammalian mono… 
Highly Cited
1971
Highly Cited
1971
Hepatic epoxide hydrase. Structure-activity relationships for substrates and inhibitors.
Highly Cited
1971
Highly Cited
1971
A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide.
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