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Hydro-Lyases

Known as: hydrase, hydro lyase, Dehydratases 
Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.
National Institutes of Health

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(R)-2-methylmalate dehydratase(S)-2-methylmalate dehydratase2,2-dimethylcyclopropanecarbonitrile hydratase, Rhodococcus boritolerans2-hydroxypentadienoic acid hydratase
In BloodProcess of secretionantagonists & inhibitorschemical synthesis

Papers overview

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Highly Cited
1986
Highly Cited
1986
Oxidative microsomal metabolism of 1-nitropyrene and DNA-binding of oxidized metabolites following nitroreduction.
1-Nitropyrene is an environmental mutagen and carcinogen which undergoes both oxidative and reductive metabolism. We have… 
1981
1981
Metabolic activation of carcinogens in the Salmonella mutagenicity assay by hamster and rat liver S-9 preparations.
Before exerting a carcinogenic or mutagenic effect, many carcinogens must undergo metabolic activation. Liver S-9 preparations… 
Highly Cited
1978
Highly Cited
1978
Reduced nicotinamide adenine dinucleotide phosphate-dependent formation of 2,3-dihydro-2,3-dihydroxyaflatoxin B1 from aflatoxin B1 by hepatic microsomes.
2,3-Dihydro-2,3-dihydroxyaflatoxin B1 (dihydrodiol) was formed as a major metabolite in the incubation of aflatoxin B1 with rat… 
Review
1977
Review
1977
Characterization of rat lung epoxide (styrene oxide) hydrase with a modified radioactive assay of improved sensitivity.
The epoxide hydrase assay developed by Oesch et al. (Biochim. Biophys. Acta, 227: 685-691, 1971) using [3H]styrene oxide as… 
1976
1976
The direct spectrophotometric observation of benzo(a)pyrene phenol formation by liver microsomes.
Optical spectral repetitive scan analysis during the oxidative metabolism of benzo(a)pyrene by liver microsomal suspensions… 
1976
1976
Specific positions involved in enzyme catalyzed covalent binding of benzo[a]pyrene to poly(G).
Covalent binding of benzo[a]pyrene to poly(G) was studied with the use of a radioactive assay and specifically labeled substrates… 
1975
1975
Inhibition of benzo(alpha)pyrene metabolism catalyzed by mouse and hamster lung microsomes.
Induced and constitutive microsomal enzymes of mouse and hamster lungs catalyze both the hydroxylation of benzo(alpha)pyrene and… 
1974
1974
Hepatic epoxide hydrase in neonatal and partially hepatectomized rats.
Summary The specific activity of epoxide hydrase was determined in rat liver both during development from the fetal to the adult… 
1974
1974
Plant carbonic anhydrase. Hydrase activity and its reversible inhibition.
1963
1963
Studies in valine biosynthesis. V. Characteristics of the purified dihydroxyacid dehydratase from spinach leaves.
An intermediate reaction in valine biosynthesis is the dehydration of Q!, /3-dihydroxyisovaleric acid to ar-ketoisovaleric acid…