Heterogeneity of cytochrome P-450s induced by polychlorinated biphenyls.

  title={Heterogeneity of cytochrome P-450s induced by polychlorinated biphenyls.},
  author={Alvito P. Alvares and A. Kappas},
  journal={The Journal of biological chemistry},
  volume={252 18},
The polychlorinated biphenyl mixture, Aroclor 1254, is a powerful inducer of both cytochromes P-450 and P-448 exhibiting the catalytic properties of both cytochromes in the liver. Addition of Aroclor 1254 to hepatic microsomes produces a type I difference spectrum. When administered to rats, the hemeprotein induced by Aroclor 1254 displayed spectral properties which are a combination of the spectral properties of the two cytochromes. The absorption maximum of the CO complex of the hemeprotein… CONTINUE READING
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