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Nomenclature and classification of purinoceptors.
TLDR
The evidence is now compelling that ATP plays important physiological and/ or pathophysiological roles in a variety of biological systems, and the presence of receptors for ADP and adenosine (presumably A2) receptors exist on platelets is compelling. Expand
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.
TLDR
F Forskolin would appear to activate adenylate cyclase through a unique mechanism involving both direct activation of the enzyme and facilitation or potentiation of the modulation of enzyme activity by receptors or the guanyl nucleotide-binding subunit, or both. Expand
Alkaloids from amphibian skin: a tabulation of over eight-hundred compounds.
A diverse array of biologically active, lipid-soluble alkaloids have been discovered in amphibian skin. Such alkaloids include the following: the steroidal samandarines from salamanders, theExpand
Further classification of skin alkaloids from neotropical poison frogs (Dendrobatidae), with a general survey of toxic/noxious substances in the amphibia.
TLDR
Cutaneous granular glands are a shared character of adult amphibians, including caecilians, and are thought to be the source of most biologically active compounds in amphibian skin, which clearly prove the defensive value of these diverse metabolites. Expand
Toxicity of Panamanian Poison Frogs (Dendrobates): Some Biological and Chemical Aspects
TLDR
A small Neotropical frog, Dendrobates pumilio, undergoes interpopulational variation in color, degree of toxicity, size, and habits, which may result from isolation and chance restriction of original heterozygosity, with subsequent selection acting on different and greatly limited mixtures of alleles. Expand
Caffeine--an atypical drug of dependence.
TLDR
Although caffeine can be argued to fulfill regulatory criteria as a dependence-producing drug, the extensive use of caffeine-containing beverages poses little apparent risk to the consumer or to society. Expand
Nicotinic Agonists, Antagonists, and Modulators From Natural Sources
  • J. Daly
  • Chemistry, Medicine
  • Cellular and Molecular Neurobiology
  • 1 June 2005
TLDR
Research on acetylcholine receptors and functions has been dependent on key natural products and the synthetic agents that they inspired, and galanthamine, codeine, and ivermectin represent positive modulators of nicotinic function, derived from natural sources. Expand
Caffeine analogs: biomedical impact
  • J. Daly
  • Chemistry, Medicine
  • Cellular and Molecular Life Sciences
  • 18 May 2007
TLDR
Caffeine and various analogs, the latter designed to enhance potency and selectivity toward specific biological targets, have played key roles in defining the nature and role of adenosine receptors, phosphodiesterases, and calcium release channels in physiological processes. Expand
Spatial and temporal patterns of alkaloid variation in the poison frog Oophaga pumilio in Costa Rica and Panama over 30 years.
TLDR
The results of this study indicate that chemical defense in a dendrobatid poison frog is dependent on geographic location and habitat type, which presumably controls the abundance and nature of alkaloid-containing arthropods. Expand
Preliminary evaluation of skin toxins and vocalizations in taxonomic and evolutionary studies of poison-dart frogs (Dendrobatidae). Bulletin of the AMNH ; v. 157, article 3
With your big selection of various publications, your search demand Preliminary Evaluation Of Skin Toxins And Vocalizations In Taxonomic And Evolutionary Studies Of Poison Dart Frogs DendrobatidaeExpand
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