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Nomenclature and classification of purinoceptors.
The evidence is now compelling that ATP plays important physiological and/ or pathophysiological roles in a variety of biological systems, and the presence of receptors for ADP and adenosine (presumably A2) receptors exist on platelets is compelling.
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.
- K. Seamon, W. Padgett, J. Daly
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 June 1981
F Forskolin would appear to activate adenylate cyclase through a unique mechanism involving both direct activation of the enzyme and facilitation or potentiation of the modulation of enzyme activity by receptors or the guanyl nucleotide-binding subunit, or both.
Alkaloids from amphibian skin: a tabulation of over eight-hundred compounds.
A diverse array of biologically active, lipid-soluble alkaloids have been discovered in amphibian skin. Such alkaloids include the following: the steroidal samandarines from salamanders, the…
Toxicity of Panamanian Poison Frogs (Dendrobates): Some Biological and Chemical Aspects
A small Neotropical frog, Dendrobates pumilio, undergoes interpopulational variation in color, degree of toxicity, size, and habits, which may result from isolation and chance restriction of original heterozygosity, with subsequent selection acting on different and greatly limited mixtures of alleles.
Further classification of skin alkaloids from neotropical poison frogs (Dendrobatidae), with a general survey of toxic/noxious substances in the amphibia.
Caffeine--an atypical drug of dependence.
Spatial and temporal patterns of alkaloid variation in the poison frog Oophaga pumilio in Costa Rica and Panama over 30 years.
Forskolin: a unique diterpene activator of cyclic AMP-generating systems.
Forskolin provides an invaluable tool for the investigation of the role of cyclic AMP in physiological responses to hormones, both through it direct activation of adenylate cyclase and through its ability to potentiate hormonal activation of the enzyme.
Caffeine analogs: biomedical impact
- J. Daly
- BiologyCellular and Molecular Life Sciences
- 18 May 2007
Caffeine and various analogs, the latter designed to enhance potency and selectivity toward specific biological targets, have played key roles in defining the nature and role of adenosine receptors, phosphodiesterases, and calcium release channels in physiological processes.
Adenosine receptors and behavioral actions of methylxanthines.
- S. Snyder, J. Katims, Z. Annau, R. F. Bruns, J. Daly
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 1 May 1981
The data strongly suggest that the behavioral stimulant effects of methylxanthines involve a blockade of central adenosine receptors.