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HTT gene

Known as: HD GENE, HUNTINGTIN, IT15 
This gene may be involved in vesicle transport.
National Institutes of Health

Related topics

Related topics

6 relations
HD protein, humanHomo sapiensHuntington DiseaseLigand Binding
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HTT wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Establishing and dissolving cohesion during the vertebrate cell cycle.
Replicated chromatids are held together from the time they emerge from the replication fork until their separation in anaphase… Expand
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Highly Cited
2005
Highly Cited
2005
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
Autophagic degradation of ubiquitinated protein aggregates is important for cell survival, but it is not known how the autophagic… Expand
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Highly Cited
2004
Highly Cited
2004
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Huntington disease is one of nine inherited neurodegenerative disorders caused by a polyglutamine tract expansion. Expanded… Expand
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Highly Cited
2004
Highly Cited
2004
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
Huntington's disease is caused by an abnormal polyglutamine expansion within the protein huntingtin and is characterized by… Expand
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Highly Cited
2004
Highly Cited
2004
Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules
Polyglutamine expansion (polyQ) in the protein huntingtin is pathogenic and responsible for the neuronal toxicity associated with… Expand
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Highly Cited
2001
Highly Cited
2001
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.
Huntingtin is a 350-kilodalton protein of unknown function that is mutated in Huntington's disease (HD), a neurodegenerative… Expand
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Highly Cited
2001
Highly Cited
2001
Impairment of the ubiquitin-proteasome system by protein aggregation.
Intracellular deposition of aggregated and ubiquitylated proteins is a prominent cytopathological feature of most… Expand
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Highly Cited
1998
Highly Cited
1998
Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions
The mechanisms by which mutant huntingtin induces neurodegeneration were investigated using a cellular model that recapitulates… Expand
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Highly Cited
1997
Highly Cited
1997
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
The cause of neurodegeneration in Huntington's disease (HD) is unknown. Patients with HD have an expanded NH2-terminal… Expand
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Highly Cited
1993
Highly Cited
1993
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
The Huntington's disease (HD) gene has been mapped in 4p16.3 but has eluded identification. We have used haplotype analysis of… Expand
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