FAQ

HTT gene

Known as: HD GENE, HUNTINGTIN, IT15 
This gene may be involved in vesicle transport.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2017
010020019882017

Related topics

Related topics

6 relations
HD protein, humanHomo sapiensHuntington DiseaseLigand Binding
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Narrower (1)

HTT wt Allele

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
HTT gene
Huntington Disease
Homo sapiens
HTT wt Allele
HD protein, human
Ligand Binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.
Trehalose, a disaccharide present in many non-mammalian species, protects cells against various environmental stresses. Whereas… (More)
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Highly Cited
2006
Highly Cited
2006
Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration
Huntington's disease (HD) is an inherited neurodegenerative disease caused by a glutamine repeat expansion in huntingtin protein… (More)
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Highly Cited
2003
Highly Cited
2003
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
Huntingtin protein is mutated in Huntington disease. We previously reported that wild-type but not mutant huntingtin stimulates… (More)
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Highly Cited
2001
Highly Cited
2001
Impairment of the ubiquitin-proteasome system by protein aggregation.
Intracellular deposition of aggregated and ubiquitylated proteins is a prominent cytopathological feature of most… (More)
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Highly Cited
2001
Highly Cited
2001
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.
Huntingtin is a 350-kilodalton protein of unknown function that is mutated in Huntington's disease (HD), a neurodegenerative… (More)
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Highly Cited
1999
Highly Cited
1999
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin.
Huntington's disease (HD) is an inherited, neurodegenerative disorder caused by the expansion of a glutamine repeat in the N… (More)
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Highly Cited
1999
Highly Cited
1999
Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.
The data we report in this study concern the types, location, numbers, forms, and composition of microscopic huntingtin… (More)
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Highly Cited
1998
Highly Cited
1998
Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions
The mechanisms by which mutant huntingtin induces neurodegeneration were investigated using a cellular model that recapitulates… (More)
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Highly Cited
1997
Highly Cited
1997
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
The cause of neurodegeneration in Huntington's disease (HD) is unknown. Patients with HD have an expanded NH2-terminal… (More)
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Highly Cited
1997
Highly Cited
1997
Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo
The mechanism by which an elongated polyglutamine sequence causes neurodegeneration in Huntington's disease (HD) is unknown. In… (More)
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