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HTT gene
Known as:
HD GENE
, HUNTINGTIN
, IT15
(More)
This gene may be involved in vesicle transport.
National Institutes of Health
Topic mentions per year
Topic mentions per year
1988-2017
0
100
200
1988
2017
Related topics
Related topics
6 relations
HD protein, human
Homo sapiens
Huntington Disease
Ligand Binding
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Narrower (1)
HTT wt Allele
Related mentions per year
Related mentions per year
1936-2018
1940
1960
1980
2000
2020
HTT gene
Huntington Disease
Homo sapiens
HTT wt Allele
HD protein, human
Ligand Binding
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.
Sovan Sarkar
,
Janet E. Davies
,
Zebo Huang
,
Alan Tunnacliffe
,
David C Rubinsztein
The Journal of biological chemistry
2007
Trehalose, a disaccharide present in many non-mammalian species, protects cells against various environmental stresses. Whereas…
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Is this relevant?
Highly Cited
2006
Highly Cited
2006
Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration
Libin Cui
,
Hyunkyung Jeong
,
Fran Borovečki
,
Christopher N. Parkhurst
,
Naoko Tanese
,
Dimitri Krainc
Cell
2006
Huntington's disease (HD) is an inherited neurodegenerative disease caused by a glutamine repeat expansion in huntingtin protein…
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Highly Cited
2003
Highly Cited
2003
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
Chiara Zuccato
,
Marzia Tartari
,
+9 authors
Elena Cattaneo
Nature Genetics
2003
Huntingtin protein is mutated in Huntington disease. We previously reported that wild-type but not mutant huntingtin stimulates…
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Highly Cited
2001
Highly Cited
2001
Impairment of the ubiquitin-proteasome system by protein aggregation.
Neil F Bence
,
Richa Sampat
,
Ron R. Kopito
Science
2001
Intracellular deposition of aggregated and ubiquitylated proteins is a prominent cytopathological feature of most…
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Highly Cited
2001
Highly Cited
2001
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.
Camila Zuccato
,
Andrea Ciammola
,
+10 authors
Elisa Cattaneo
Science
2001
Huntingtin is a 350-kilodalton protein of unknown function that is mutated in Huntington's disease (HD), a neurodegenerative…
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Highly Cited
1999
Highly Cited
1999
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin.
Guntram Schilling
,
Meriam Becher
,
+11 authors
David R Borchelt
Human molecular genetics
1999
Huntington's disease (HD) is an inherited, neurodegenerative disorder caused by the expansion of a glutamine repeat in the N…
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Highly Cited
1999
Highly Cited
1999
Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.
Claire-Anne Gutekunst
,
S. H. Li
,
+7 authors
X. J. Li
The Journal of neuroscience : the official…
1999
The data we report in this study concern the types, location, numbers, forms, and composition of microscopic huntingtin…
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Highly Cited
1998
Highly Cited
1998
Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions
Frédéric Saudou
,
Steven M. Finkbeiner
,
Didier Devys
,
Michael E. Greenberg
Cell
1998
The mechanisms by which mutant huntingtin induces neurodegeneration were investigated using a cellular model that recapitulates…
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Highly Cited
1997
Highly Cited
1997
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
M Difiglia
,
Ellen Sapp
,
+4 authors
Neil Aronin
Science
1997
The cause of neurodegeneration in Huntington's disease (HD) is unknown. Patients with HD have an expanded NH2-terminal…
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Highly Cited
1997
Highly Cited
1997
Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo
Eberhard Scherzinger
,
Rudi Lurz
,
+7 authors
Erich E. Wanker
Cell
1997
The mechanism by which an elongated polyglutamine sequence causes neurodegeneration in Huntington's disease (HD) is unknown. In…
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