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HTT gene

Known as: HD GENE, HUNTINGTIN, IT15 
This gene may be involved in vesicle transport.
National Institutes of Health

Related topics

Related topics

6 relations
HD protein, humanHomo sapiensHuntington DiseaseLigand Binding

Narrower (1)

HTT wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
IP3 receptor/Ca2+ channel: from discovery to new signaling concepts
Inositol 1,4,5‐trisphosphate (IP3) is a second messenger that induces the release of Ca2+ from the endoplasmic reticulum (ER… 
Review
2004
Review
2004
Huntingtin-protein interactions and the pathogenesis of Huntington's disease.
Highly Cited
2004
Highly Cited
2004
Mutant Huntingtin Impairs Axonal Trafficking in Mammalian Neurons In Vivo and In Vitro
ABSTRACT Recent data in invertebrates demonstrated that huntingtin (htt) is essential for fast axonal trafficking. Here, we… 
Highly Cited
2004
Highly Cited
2004
Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation.
Highly Cited
2004
Highly Cited
2004
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Review
2003
Review
2003
Huntingtin aggregation and toxicity in Huntington's disease
Highly Cited
2002
Highly Cited
2002
Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's Disease
Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion of a polyglutamine tract in the… 
Highly Cited
1999
Highly Cited
1999
A YAC Mouse Model for Huntington’s Disease with Full-Length Mutant Huntingtin, Cytoplasmic Toxicity, and Selective Striatal Neurodegeneration
Highly Cited
1996
Highly Cited
1996
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
Apoptosis has recently been recognized as a mode of cell death in Huntington disease (HD). Apopain, a human counterpart of the… 
Highly Cited
1995
Highly Cited
1995
A huntingtin-associated protein enriched in brain with implications for pathology
HUNTINGTON's disease (HD) is an autosomal dominant neuro-degenerative disorder caused by an expanding polyglutamine repeat in the… 
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