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HTT gene

Known as: HD GENE, HUNTINGTIN, IT15 
This gene may be involved in vesicle transport.
National Institutes of Health

Related topics

Related topics

6 relations
HD protein, humanHomo sapiensHuntington DiseaseLigand Binding

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HTT wt Allele

Papers overview

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Highly Cited
2010
Highly Cited
2010
Huntingtin Interacts with the Cue Domain of gp78 and Inhibits gp78 Binding to Ubiquitin and p97/VCP
Huntington's disease (HD) is caused by polyglutamine expansion in huntingtin (htt) protein, but the exact mechanism of HD… 
Highly Cited
2005
Highly Cited
2005
Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment
Highly Cited
2004
Highly Cited
2004
Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease.
Huntington disease (HD) is an inherited neurodegenerative disease caused by expansion of a polyglutamine tract near the N… 
Highly Cited
2004
Highly Cited
2004
Hsp70 dynamics in vivo: effect of heat shock and protein aggregation
The molecular chaperone Hsp70 interacts with misfolded proteins and also accumulates in the nucleus during heat shock. Using GFP… 
Review
2004
Review
2004
Huntington’s disease: pathomechanism and therapeutic perspectives
Summary.Huntington’s disease is an autosomal dominantly inherited progressive neurodegenerative disorder. The mutant gene has… 
Highly Cited
2003
Highly Cited
2003
Depletion of wild‐type huntingtin in mouse models of neurologic diseases
Huntington's disease (HD) is caused by a mutation in the gene encoding for huntingtin resulting in selective neuronal… 
Highly Cited
2002
Highly Cited
2002
Imaging gene expression in the brain in vivo in a transgenic mouse model of Huntington's disease with an antisense radiopharmaceutical and drug-targeting technology.
UNLABELLED Disease-specific genes of unknown function can be imaged in vivo with antisense radiopharmaceuticals, providing the… 
Highly Cited
1999
Highly Cited
1999
Corrigendum: Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin (Human Molecular Genetics (1999) 8 (397-407))
Highly Cited
1996
Highly Cited
1996
Differential Expression of Normal and Mutant Huntington's Disease Gene Alleles
Huntingtin expression was examined by Western blot and immunoprecipitation studies of lymphoblastoid cell lines from Huntington's… 
Highly Cited
1993
Highly Cited
1993
Analysis of the huntingtin gene reveals a trinucleotide-length polymorphism in the region of the gene that contains two CCG-rich stretches and a correlation between decreased age of onset of…
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