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HTT gene

Known as: HD GENE, HUNTINGTIN, IT15 
This gene may be involved in vesicle transport.
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Replicated chromatids are held together from the time they emerge from the replication fork until their separation in anaphase… Expand
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Highly Cited
2005
Highly Cited
2005
Autophagic degradation of ubiquitinated protein aggregates is important for cell survival, but it is not known how the autophagic… Expand
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Highly Cited
2004
Highly Cited
2004
Huntington disease is one of nine inherited neurodegenerative disorders caused by a polyglutamine tract expansion. Expanded… Expand
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Highly Cited
2004
Highly Cited
2004
Huntington's disease is caused by an abnormal polyglutamine expansion within the protein huntingtin and is characterized by… Expand
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Highly Cited
2004
Highly Cited
2004
Polyglutamine expansion (polyQ) in the protein huntingtin is pathogenic and responsible for the neuronal toxicity associated with… Expand
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Highly Cited
2001
Highly Cited
2001
Huntingtin is a 350-kilodalton protein of unknown function that is mutated in Huntington's disease (HD), a neurodegenerative… Expand
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Highly Cited
2001
Highly Cited
2001
Intracellular deposition of aggregated and ubiquitylated proteins is a prominent cytopathological feature of most… Expand
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Highly Cited
1998
Highly Cited
1998
The mechanisms by which mutant huntingtin induces neurodegeneration were investigated using a cellular model that recapitulates… Expand
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Highly Cited
1997
Highly Cited
1997
The cause of neurodegeneration in Huntington's disease (HD) is unknown. Patients with HD have an expanded NH2-terminal… Expand
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Highly Cited
1993
Highly Cited
1993
The Huntington's disease (HD) gene has been mapped in 4p16.3 but has eluded identification. We have used haplotype analysis of… Expand
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