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The epidemiology of multiple sclerosis in Europe
Comparing epidemiological indices among European countries is a hard task and often leads only to approximate estimates, which represents a major methodological concern when evaluating the MS burden in Europe and when implementing specific cost‐of‐illness studies.
EFNS guideline on mild traumatic brain injury: report of an EFNS task force
In 1999, a Task Force on Mild Traumatic Brain Injury (MTBI) was set up under the auspices of the European Federation of Neurological Societies. Its aim was to propose an acceptable uniform…
Kynurenines in the CNS: recent advances and new questions
This Review highlights the involvement of the kynurenine system in the pathology of neurodegenerative disorders, pain syndromes and autoimmune diseases through a detailed discussion of its potential implications in Huntington's disease, migraine and multiple sclerosis.
Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders
The kynurenine system and immunoregulation
There is developing interest in the role of the kynurenines in the immune function and the anti-inflammatory effect of kynurenic acid provides a further feedback mechanism in modulating the immune responses.
Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled,…
The Alzheimer’s Association external quality control program for cerebrospinal fluid biomarkers
Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis
Subcutaneous nitroglycerin produced a significant increase of nitric oxide synthase (NOS)- and c-fos-immunoreactive neurons in the cervical part of trigeminal nucleus caudalis in rats after 4 h, which may be relevant for central sensitization and the understanding of its effect in migraine.
Large motor units are selectively affected following a stroke
Alterations in PACAP-38-like immunoreactivity in the plasma during ictal and interictal periods of migraine patients
- B. Tuka, Z. Helyes, J. Tajti
- Medicine, BiologyCephalalgia : an international journal of…
- 18 April 2013
This is the first study that has provided evidence of a clear association between migraine phases (ictal and interictal) and plasma PACAP-38-LI alterations.