Skip to search formSkip to main contentSkip to account menu
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
TLDR
In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
View on Nature
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
TLDR
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
View on Taylor & Francis
TFEB Links Autophagy to Lysosomal Biogenesis
TLDR
A mitogen-activated protein kinase–dependent mechanism regulates autophagy by controlling the biogenesis and partnership of two distinct cellular organelles during starvation.
View on Publisher
Regulation of mammalian autophagy in physiology and pathophysiology.
TLDR
This review focuses on mammalian autophagy, and an overview of the understanding of its machinery and the signaling cascades that regulate it is given, and the possibility of autophagic upregulation as a therapeutic approach for various conditions is considered.
View on PubMed
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
TLDR
A two-stage genome-wide association study of Alzheimer's disease involving over 16,000 individuals found strong evidence for association to APOE, and observed more variants associated at p< 1×10 − 5 than expected by chance.
View on Nature
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
TLDR
This work shows that mammalian target of rapamycin (mTOR) is sequestered in polyglutamine aggregates in cell models, transgenic mice and human brains, and provides proof-of-principle for the potential of inducing autophagy to treat Huntington disease.
View on Nature
Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease
TLDR
Meta-analyses of all data provided compelling evidence that ABCA7 and the MS4A gene cluster are new Alzheimer's disease susceptibility loci and independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance.
View on Nature
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
TLDR
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed.
View on Springer
α-Synuclein Is Degraded by Both Autophagy and the Proteasome*
TLDR
It was found that not only is α-synuclein degraded by the proteasome, but it is also degraded by autophagy, which merits consideration as a potential therapeutic for Parkinsons disease, as it is designed for chronic use in humans.
View on Publisher
Letter abstract - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's Disease
TLDR
A two-stage genome-wide association study of Alzheimer's disease involving over 16,000 individuals, the most powerful AD GWAS to date, produced compelling evidence for association with Alzheimer's Disease in the combined dataset.
View via Publisher
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License