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Over the last three decades, advances in biochemical pathology and human genetics have illuminated one of the most enigmatic… Expand Huntington's disease is a progressive, fatal, neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene… Expand Huntington's disease may present at any age, but most typically manifests between the ages of 35 and 45 years as a slowly… Expand Huntington disease is one of nine inherited neurodegenerative disorders caused by a polyglutamine tract expansion. Expanded… Expand Huntingtin is a 350-kilodalton protein of unknown function that is mutated in Huntington's disease (HD), a neurodegenerative… Expand ! The Unified Huntington’s Disease Rating Scale (UHDRS) was developed as a clinical rating scale to assess four domains of… Expand The Unified Huntington's disease Rating Scale (UHDRS) was developed as a clinical rating scale to assess four domains of clinical… Expand Huntington's disease (HD) is an autosomal dominant neurological disorder characterized by progressive chorea, cognitive… Expand In postmortem brain specimens from 163 clinically diagnosed cases of Huntington's disease (HD) the striatum exhibited marked… Expand Family studies show that the Huntington's disease gene is linked to a polymorphic DNA marker that maps to human chromosome 4. The… Expand