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Baclofen

Known as: Chlorophenyl GABA, Baclofenum, beta-(4-Chlorophenyl)gaba 
A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
BACKGROUND Intervention to achieve alcohol abstinence represents the most effective treatment for alcohol-dependent patients with… Expand
Highly Cited
2002
Highly Cited
2002
AIMS The gamma-aminobutyric acid (GABA(B)) receptor agonist, baclofen, has recently been shown to reduce alcohol intake in… Expand
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Review
1995
Review
1995
The inhibitory neurotransmitter GABA acts in the mammalian brain through two different receptor classes: GABAA and GABAB… Expand
Highly Cited
1993
Highly Cited
1993
A total of 93 patients with intractable spasticity due to either spinal cord injury (59 cases), multiple sclerosis (31 cases), or… Expand
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Highly Cited
1992
Highly Cited
1992
Presynaptic inhibition of neurotransmitter release is thought to be mediated by a reduction of axon terminal Ca2+ current. We… Expand
Highly Cited
1991
Highly Cited
1991
Seventeen patients with congenital spastic cerebral palsy and six patients with other forms of spasticity were injected… Expand
Highly Cited
1989
Highly Cited
1989
We studied the effect of the intrathecal infusion of baclofen, an agonist of gamma-aminobutyric acid, on abnormal muscle tone and… Expand
Highly Cited
1985
Highly Cited
1985
Baclofen is the most effective drug for the treatment of rigidity and spasms caused by damage to the spinal cord, but frequently… Expand
Highly Cited
1981
Highly Cited
1981
The presence of a novel receptor for the neurotransmitter γ-aminobutyric acid (GABA) on peripheral autononric nerve terminals and… Expand
Highly Cited
1980
Highly Cited
1980
The existence of a receptor for γ-aminobutyric acid (GABA) on neurones of the mammalian central nervous system (CNS) is now… Expand