Baclofen

Known as: Chlorophenyl GABA, Baclofenum, beta-(4-Chlorophenyl)gaba 
A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND Recent clinical trials and case-reports indicate that baclofen, a GABA(B) agonist, may have efficacy for alcohol… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Intervention to achieve alcohol abstinence represents the most effective treatment for alcohol-dependent patients with… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Omeprazole controls acid but not non-acid reflux. The GABA B agonist baclofen decreases acid reflux through the… (More)
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Highly Cited
2002
Highly Cited
2002
AIMS The gamma-aminobutyric acid (GABA(B)) receptor agonist, baclofen, has recently been shown to reduce alcohol intake in… (More)
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Highly Cited
1999
Highly Cited
1999
An emerging hypothesis to explain the mechanism of heroin-induced positive reinforcement states that opiates inhibit gamma… (More)
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Highly Cited
1998
Highly Cited
1998
We observed a marked prolongation of the transcranially evoked silent period during continuous intrathecal administration of high… (More)
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Highly Cited
1996
Highly Cited
1996
The effect of the GABAB agonist baclofen on cocaine self-administration in the rat was investigated. In the first experiment… (More)
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Highly Cited
1992
Highly Cited
1992
Presynaptic inhibition of neurotransmitter release is thought to be mediated by a reduction of axon terminal Ca2+ current. We… (More)
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Highly Cited
1985
Highly Cited
1985
Baclofen is the most effective drug for the treatment of rigidity and spasms caused by damage to the spinal cord, but frequently… (More)
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Highly Cited
1980
Highly Cited
1980
The existence of a receptor for γ-aminobutyric acid (GABA) on neurones of the mammalian central nervous system (CNS) is now… (More)
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