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Baclofen

Known as: Chlorophenyl GABA, Baclofenum, beta-(4-Chlorophenyl)gaba 
A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side effects caused by antineoplastic agents, with… Expand
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Highly Cited
2002
Highly Cited
2002
AIMS The gamma-aminobutyric acid (GABA(B)) receptor agonist, baclofen, has recently been shown to reduce alcohol intake in… Expand
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Review
1995
Review
1995
The inhibitory neurotransmitter GABA acts in the mammalian brain through two different receptor classes: GABAA and GABAB… Expand
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Highly Cited
1993
Highly Cited
1993
A total of 93 patients with intractable spasticity due to either spinal cord injury (59 cases), multiple sclerosis (31 cases), or… Expand
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Highly Cited
1993
Highly Cited
1993
OBJECTIVE To determine if continuous intrathecal baclofen infusion (CIBI) would provide continuous relief of spasticity in… Expand
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Highly Cited
1992
Highly Cited
1992
Presynaptic inhibition of neurotransmitter release is thought to be mediated by a reduction of axon terminal Ca2+ current. We… Expand
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Highly Cited
1989
Highly Cited
1989
We studied the effect of the intrathecal infusion of baclofen, an agonist of gamma-aminobutyric acid, on abnormal muscle tone and… Expand
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Highly Cited
1985
Highly Cited
1985
Baclofen is the most effective drug for the treatment of rigidity and spasms caused by damage to the spinal cord, but frequently… Expand
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Highly Cited
1981
Highly Cited
1981
The presence of a novel receptor for the neurotransmitter γ-aminobutyric acid (GABA) on peripheral autononric nerve terminals and… Expand
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Highly Cited
1980
Highly Cited
1980
The existence of a receptor for γ-aminobutyric acid (GABA) on neurones of the mammalian central nervous system (CNS) is now… Expand
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