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Protein S-nitrosylation: purview and parameters
- D. Hess, Akio Matsumoto, Sung-Oog Kim, H. E. Marshall, J. Stamler
- BiologyNature Reviews Molecular Cell Biology
- 1 February 2005
S-nitrosylation conveys a large part of the ubiquitous influence of nitric oxide on cellular signal transduction, and provides a mechanism for redox-based physiological regulation.
A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans
It is concluded that GSNO reductase is evolutionarily conserved from bacteria to humans, is critical for SNO homeostasis, and protects against nitrosative stress.
Nitric oxide in skeletal muscle
It is shown that rat skeletal muscle expresses neuronal-type NO synthase and that activity varies among several respiratory and limb muscles, and that two physiological functions of NO in skeletal muscle are supported.
Biochemistry of nitric oxide and its redox-activated forms.
The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.
Nitrosylation The Prototypic Redox-Based Signaling Mechanism
Identification of the enzymatic mechanism of nitroglycerin bioactivation
- Zhiqiang Chen, Jian Zhang, J. Stamler
- BiologyProceedings of the National Academy of Sciences…
- 4 June 2002
These results demonstrate that the biotransformation of GTN occurs predominantly in mitochondria through a novel reductase action of mtALDH and suggest that nitrite is an obligate intermediate in generation of NO bioactivity.
Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation.
Results reveal that ion channels can differentiate nitrosative from oxidative signals and indicate that the cardiac calcium release channel (ryanodine receptor) in canines is regulated by posttranslational chemical modification(s) of sulfurs.
Physiology of nitric oxide in skeletal muscle.
These studies provide new insights into fundamental aspects of muscle physiology, cell biology, ion channel physiology, calcium homeostasis, signal transduction, and the biochemistry of redox-related systems.
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
It is reported that NO.-mediated neurotoxicity is engendered, at least in part, by reaction with superoxide anion (O.-2), apparently leading to formation of peroxynitrite (ONOO−), and not by NO.
S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.
- J. Stamler, D. Simon, J. Loscalzo
- Biology, ChemistryProceedings of the National Academy of Sciences…
It is demonstrated that S-nitroso proteins form readily under physiologic conditions and possess EDRF-like effects of vasodilation and platelet inhibition, suggesting that S -nitrosothiol groups in proteins may serve as intermediates in the cellular metabolism of NO and raise the possibility of an additional type of cellular regulatory mechanism.