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HSPA5 protein, human

Known as: Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein grp78, heat shock 70kDa protein 5, human, Immunoglobulin Heavy Chain-Binding Protein 
78 kDa glucose-regulated protein (654 aa, ~72kDa) is encoded by HSPA5 gene. The protein is intracellularly localized in the endoplasmic reticulum… 
National Institutes of Health

Related topics

Related topics

10 relations
Endoplasmic ReticulumHSPA5 geneHSPA5 wt AlleleNegative Regulation of Apoptosis

Broader (1)

molecular chaperone GRP78

Papers overview

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2013
2013
Modelling the effect of GRP78 on anti-oestrogen sensitivity and resistance in breast cancer
Understanding the origins of resistance to anti-oestrogen drugs is of critical importance to many breast cancer patients. Recent… 
2010
2010
Gastrointestinal , Hepatobiliary and Pancreatic Pathology Grp 78 Heterozygosity Regulates Chaperone Balance in Exocrine Pancreas with Differential Response to Cerulein-Induced Acute Pancreatitis
The endoplasmic reticulum (ER) is abundant in the acinar cells of the exocrine pancreas. To test the role of ER homeostasis in… 
Highly Cited
2009
Highly Cited
2009
The Endoplasmic Reticulum Chaperone BiP/GRP78 Is Important in the Structure and Function of the Human Cytomegalovirus Assembly Compartment
ABSTRACT We previously demonstrated that the endoplasmic reticulum (ER) chaperone BiP functions in human cytomegalovirus (HCMV… 
2008
2008
Suppression of cytokine responses by indomethacin in podocytes: a mechanism through induction of unfolded protein response.
We found that, in murine podocytes, expression of monocyte chemoattractant protein 1 (MCP-1) in response to TNF-alpha was… 
2007
2007
Regulatory proteins of eukaryotic initiation factor 2‐alpha subunit (eIF2α) phosphatase, under ischemic reperfusion and tolerance
Phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α), which is one of the substrates of protein… 
2001
2001
Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibit its ATPase activity in human fibroblasts
Salicylic acid (SA), an endogenous signaling molecule of plants, possesses anti‐inflammatory and anti‐neoplastic actions in human… 
1998
1998
Targeting of endoplasmic reticulum-associated proteins to axons and dendrites in rotavirus-infected neurons
1996
1996
Co-expression of the alpha subunit of human prolyl 4-hydroxylase with BiP polypeptide in insect cells leads to the formation of soluble and insoluble complexes. Soluble alpha-subunit-BiP complexes…
Prolyl 4-hydroxylase (EC 1.14.11.2) catalyses the post-translational formation of 4-hydroxyproline in collagens. The vertebrate… 
Highly Cited
1994
Highly Cited
1994
Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation.
We have previously demonstrated that several endoplasmic reticulum (ER) proteins, including BiP, ERp72, grp94, and protein… 
1988
1988
78-kilodalton glucose-regulated protein is induced in Rous sarcoma virus-transformed cells independently of glucose deprivation
To identify mRNAs with altered expression in Rous sarcoma virus (RSV)-transformed cells, we screened a chicken embryo fibroblast… 
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