HSPA5 protein, human

Known as: Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein grp78, heat shock 70kDa protein 5, human, Immunoglobulin Heavy Chain-Binding Protein 
78 kDa glucose-regulated protein (654 aa, ~72kDa) is encoded by HSPA5 gene. The protein is intracellularly localized in the endoplasmic reticulum… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2018
0204019862018

Papers overview

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Highly Cited
2010
Highly Cited
2010
The unfolded protein response (UPR) is an intracellular signaling pathway that counteracts variable stresses that impair protein… (More)
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Highly Cited
2008
Highly Cited
2008
The unfolded protein response (UPR) is an evolutionarily conserved mechanism that activates both proapoptotic and survival… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND & AIMS Nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) are associated with known triggers of… (More)
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Highly Cited
2006
Highly Cited
2006
GRP78, also known as BiP, is a central regulator of endoplasmic reticulum (ER) homeostasis due to its multiple functional roles… (More)
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Highly Cited
2005
Highly Cited
2005
The multiple implications of ER stress and the unfolded protein response in health and disease highlight the importance of… (More)
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Highly Cited
2003
Highly Cited
2003
A large number of correlative studies have established that the activation of the unfolded protein response (UPR) alters the cell… (More)
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Highly Cited
2002
Highly Cited
2002
ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER… (More)
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Highly Cited
1999
Highly Cited
1999
The 78-kDa glucose-regulated protein (GRP78) is localized in the endoplasmic reticulum (ER), and its expression is increased by… (More)
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Highly Cited
1989
Highly Cited
1989
Two members of the hsp70 family, termed hsc70 and BiP, have been implicated in promoting protein folding and assembly processes… (More)
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Highly Cited
1986
Highly Cited
1986
We have characterized a cDNA clone that encodes a protein related to the 70 kd heat shock protein, but is expressed in normal rat… (More)
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