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Pathogenesis and Diagnosis of Shiga Toxin-Producing Escherichia coli Infections
SUMMARY Since their initial recognition 20 years ago, Shiga toxin-producing Escherichia coli (STEC) strains have emerged as an important cause of serious human gastrointestinal disease, which mayExpand
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Detection and characterization of Shiga toxigenic Escherichia coli by using multiplex PCR assays for stx1, stx2, eaeA, enterohemorrhagic E. coli hlyA, rfbO111, and rfbO157.
Shiga toxigenic Escherichia coli (STEC) comprises a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, certain strains appear to be ofExpand
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The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease
Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the mucosal surfaces of the host nasopharynx and upper airway. Through a combination of virulence-factor activity and anExpand
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Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection
Streptococcus pneumoniae is one of the leading causes of invasive bacterial disease worldwide. Fragments of the cell wall and the cytolytic toxin pneumolysin have been shown to contributeExpand
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Characterization of Saa, a Novel Autoagglutinating Adhesin Produced by Locus of Enterocyte Effacement-Negative Shiga-ToxigenicEscherichia coli Strains That Are Virulent for Humans
ABSTRACT The capacity of Shiga toxigenic Escherichia coli(STEC) to adhere to the intestinal mucosa undoubtedly contributes to pathogenesis of human disease. The majority of STEC strains isolated fromExpand
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Molecular Characterization of a Shiga ToxigenicEscherichia coli O113:H21 Strain Lacking eaeResponsible for a Cluster of Cases of Hemolytic-Uremic Syndrome
ABSTRACT Shiga toxigenic Escherichia coli (STEC) strains are a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, certain strains appearExpand
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A New Family of Potent AB5 Cytotoxins Produced by Shiga Toxigenic Escherichia coli
The Shiga toxigenic Escherichia coli (STEC) O113:H21 strain 98NK2, which was responsible for an outbreak of hemolytic uremic syndrome, secretes a highly potent and lethal subtilase cytotoxin that isExpand
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Detection and Characterization of Shiga ToxigenicEscherichia coli by Using Multiplex PCR Assays forstx1, stx2,eaeA, Enterohemorrhagic E. coli hlyA,rfbO111, andrfbO157
ABSTRACT Shiga toxigenic Escherichia coli (STEC) comprises a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, certain strains appear toExpand
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The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice
The complement system is an important component of the innate immune response to bacterial pathogens, including Streptococcus pneumoniae. The classical complement pathway is activated byExpand
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Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis
Life and death and quality control When cells are subjected to too much stress, they curl up their toes and die. Lu et al. describe a clever strategy cells use to stay alive as long as they are notExpand
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