Negative Regulation of Apoptosis
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Survivin, a member of the family of inhibitor of apoptosis proteins, functions as a key regulator of mitosis and programmed cell… Expand BackgroundRecently, a small population of cancer stem cells in adult and pediatric brain tumors has been identified. Some… Expand During apoptosis, mitochondrial membrane permeability (MMP) increases and the release into the cytosol of pro-apoptotic factors… Expand Progression of the cell cycle and control of apoptosis (programmed cell death) are thought to be intimately linked processes… Expand ABSTRACT Stat3 activation has been associated with cytokine-induced proliferation, anti-apoptosis, and transformation… Expand Inhibitors of apoptosis and of excitotoxic cell death reduce brain damage after transient and permanent middle cerebral artery… Expand Inhibitors of programmed cell death (apoptosis) aberrantly prolonging cell viability may contribute to cancer1 by facilitating… Expand The protooncogene Bcl-2 functions as a suppressor of apoptosis in growth factor-dependent cells, but a post-receptor signaling… Expand gp130 is a common signal transducer for the interleukin-6-related cytokines. To delineate the gp130-mediated growth signal, we… Expand BCL-2 was isolated from the t(14;18) chromosomal breakpoint in follicular B-cell lymphoma1–3. Bcl-2 has the unique oncogenic role… Expand