Negative Regulation of Apoptosis

Recently, a small population of cancer stem cells in adult and pediatric brain tumors has been identified. Some evidence has… (More)

Evasion of apoptosis is a hallmark of cancer, but the molecular circuitries of this process are not understood. Here we show that… (More)

Survivin is a member of the inhibitor of apoptosis protein (IAP) family that has been implicated in both apoptosis inhibition and… (More)

Progression of the cell cycle and control of apoptosis (programmed cell death) are thought to be intimately linked processes… (More)

Inhibitors of programmed cell death (apoptosis) may regulate tissue differentiation and aberrantly promote cell survival in… (More)

Inhibitors of apoptosis and of excitotoxic cell death reduce brain damage after transient and permanent middle cerebral artery… (More)

Inhibitors of programmed cell death (apoptosis) aberrantly prolonging cell viability may contribute to cancer1 by facilitating… (More)

The protooncogene Bcl-2 functions as a suppressor of apoptosis in growth factor-dependent cells, but a post-receptor signaling… (More)

gp130 is a common signal transducer for the interleukin-6-related cytokines. To delineate the gp130-mediated growth signal, we… (More)

BCL-2 was isolated from the t(14;18) chromosomal breakpoint in follicular B-cell lymphoma1–3. Bcl-2 has the unique oncogenic role… (More)