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BAG Family Molecular Chaperone Regulator 3, human

Known as: BAG-3, BAG Family Molecular Chaperone Regulator 3, Bcl-2-Binding Protein Bis 
BAG family molecular chaperone regulator 3 (575 aa, ~62 kDa) is encoded by the human BAG3 gene. This protein is involved in both protein chaperone… 
National Institutes of Health

Related topics

Related topics

6 relations
Apoptosis InhibitorBAG3 geneCytoplasmic matrixGenes, Regulator

Papers overview

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Highly Cited
2016
Highly Cited
2016
Gold-nanorods-siRNA nanoplex for improved photothermal therapy by gene silencing.
Review
2016
Review
2016
Breaking BAG: The Co-Chaperone BAG3 in Health and Disease.
Highly Cited
2014
Highly Cited
2014
BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta
Eukaryotic cells use autophagy and the ubiquitin–proteasome system as their major protein degradation pathways. Upon proteasomal… 
Highly Cited
2011
Highly Cited
2011
BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy.
Highly Cited
2011
Highly Cited
2011
BAG3 and friends: Co-chaperones in selective autophagy during aging and disease
There is a reciprocal change in the expression of two members of the BAG (Bcl-2-associated athanogen) family, BAG1 and BAG3… 
Highly Cited
2010
Highly Cited
2010
BAG3 and Hsc70 Interact With Actin Capping Protein CapZ to Maintain Myofibrillar Integrity Under Mechanical Stress
Rationale: A homozygous disruption or genetic mutation of the bag3 gene, a member of the Bcl-2–associated athanogene (BAG) family… 
Highly Cited
2009
Highly Cited
2009
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
The Hsc/Hsp70 co‐chaperones of the BAG (Bcl‐2‐associated athanogene) protein family are modulators of protein quality control. We… 
Highly Cited
2008
Highly Cited
2008
Mutation in BAG3 causes severe dominant childhood muscular dystrophy
Myofibrillar myopathies (MFMs) are morphologically distinct but genetically heterogeneous muscular dystrophies in which… 
Highly Cited
2007
Highly Cited
2007
BAG3 regulates motility and adhesion of epithelial cancer cells.
BAG3 protein binds to and regulates Hsp70 chaperone activity. The BAG3 protein contains a WW domain and a proline-rich region… 
Highly Cited
2001
Highly Cited
2001
The anti‐apoptotic protein BAG‐3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines
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