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BAG Family Molecular Chaperone Regulator 3, human

Known as: BAG-3, BAG Family Molecular Chaperone Regulator 3, Bcl-2-Binding Protein Bis 
BAG family molecular chaperone regulator 3 (575 aa, ~62 kDa) is encoded by the human BAG3 gene. This protein is involved in both protein chaperone… 
National Institutes of Health

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Apoptosis InhibitorBAG3 geneCytoplasmic matrixGenes, Regulator

Papers overview

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2019
2019
p53‐dependent transcriptional suppression of BAG3 protects cells against metabolic stress via facilitation of p53 accumulation
Solid tumour frequently undergoes metabolic stress during tumour development because of inadequate blood supply and the high… 
2019
2019
BAG3 Suppresses Loading of Ago2 to IL6 mRNA in Pancreatic Ductal Adenocarcinoma
Pancreatic stellate cells (PSCs) are a subset of pancreatic cancer-associated fibroblasts, which play a critical role in… 
2019
2019
Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation
Parkinson’s disease (PD) is characterized by a chronic loss of dopaminergic neurons and the presence of proteinaceous inclusions… 
2018
2018
Upregulation of BAG 3 with apoptotic and autophagic activities in maggot extract ‐ promoted rat skin wound healing
Maggot extract (ME) accelerates rat skin wound healing, however its effect on cell maintenance in wound tissues remains unclear… 
2017
2017
BAG3 localizes in axonal structures during neuronal differentiation and is expressed in cellular processes of migrating cells in mouse cerebral cortex
BAG3 protein belongs to the family of co-chaperones involved in protein quality control and in the clearance of misfolded… 
2016
2016
BAG3-vermittelte selektive Makroautophagie bei Proteinstress und Alterung
2013
2013
BAG3 protects Bovine Papillomavirus type 1-transformed equine fibroblasts against pro-death signals
In human cancer cells, BAG3 protein is known to sustain cell survival. Here, for the first time, we demonstrate the expression of… 
2013
2013
Study of the functional consequences of BAG3 molecular variants associated with human dilated cardiomyopathy
Idiopathic dilated cardiomyopathy (DCM) is a rare disease defined by the presence of left ventricular dilatation and cardiac… 
2011
2011
Caspase-dependent cleavage of BAG3 associated with pancreatic cancer cell apoptosis
OBJECTIVE:We have previously reported that BAG3 was cleaved when thyroid cancer cell apoptosis was induced by proteasome… 
2010
2010
Caspase-dependent cleavage of BAG3 in proteasome inhibitors-induced apoptosis in thyroid cancer cells
OBJECTIVE:To investigate the role of BAG3 in proteasome inhibitor-mediated apoptosis in thyroid cancer cells.METHODS:ARO… 
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