HCRT protein, human

Known as: Preproorexin, Prepro-Orexin, Hcrt 
Orexin (131 aa, ~13 kDa) is encoded by the human HCRT gene. This protein is involved in neuropeptide-dependent signaling and feeding behavior.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Active neurons have a high demand for energy substrate, which is thought to be mainly supplied as lactate by astrocytes. Heavy… (More)
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Review
2010
Review
2010
One hypocretin/orexin (hcrt) gene has been identified in several fish species. The first pufferfish gene was identified in 2002… (More)
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Review
2010
Review
2010
Multiple lines of evidence indicate that hypocretin/orexin (HCRT) participates in the regulation of arousal and arousal-related… (More)
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2008
2008
The hypocretin/orexin (HCRT) neuropeptide system modulates behavioral state and state-dependent processes via actions on multiple… (More)
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Highly Cited
2007
Highly Cited
2007
The role of hypocretin (orexin; hcrt/orx) neurons in regulation of arousal is well established. Recently, hcrt/orx has been… (More)
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Highly Cited
2005
Highly Cited
2005
Huntington's disease (HD) is a devastating neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding… (More)
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Highly Cited
2003
Highly Cited
2003
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food… (More)
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Highly Cited
2003
Highly Cited
2003
Hypocretin/orexin modulates sleep-wake state via actions across multiple terminal fields. Within waking, hypocretin may also… (More)
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Highly Cited
2002
Highly Cited
2002
The hypocretins (hcrt1 and hcrt2) are expressed by a discrete population of hypothalamic neurons projecting to many regions of… (More)
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Highly Cited
2000
Highly Cited
2000
Recent studies demonstrated that noradrenergic locus coeruleus (LC) neurons are a particularly strong target of the novel… (More)
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