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HCRT protein, human

Known as: Preproorexin, Prepro-Orexin, Hcrt 
Orexin (131 aa, ~13 kDa) is encoded by the human HCRT gene. This protein is involved in neuropeptide-dependent signaling and feeding behavior.
National Institutes of Health

Related topics

Related topics

7 relations
Desire for foodExtracellular SpaceG Protein-Coupled Receptor SignalingHCRT gene

Broader (1)

orexins

Papers overview

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Review
2010
Review
2010
Hypocretin/orexin in arousal and stress
Highly Cited
2008
Highly Cited
2008
Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons
The hypocretin/orexin (HCRT) neuropeptide system modulates behavioral state and state‐dependent processes via actions on multiple… 
Highly Cited
2007
Highly Cited
2007
A Role for Hypocretin (Orexin) in Male Sexual Behavior
The role of hypocretin (orexin; hcrt/orx) neurons in regulation of arousal is well established. Recently, hcrt/orx has been… 
Highly Cited
2006
Highly Cited
2006
Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area
Hypocretins (HCRTs) modulate a variety of behavioral and physiological processes, in part via interactions with multiple… 
Highly Cited
2005
Highly Cited
2005
Orexin loss in Huntington's disease.
Huntington's disease (HD) is a devastating neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding… 
Review
2004
Review
2004
Hypocretin (orexin): role in normal behavior and neuropathology.
The hypocretins (Hcrts, also known as orexins) are two peptides, both synthesized by a small group of neurons, most of which are… 
Highly Cited
2003
Highly Cited
2003
Fos immunoreactivity in hypocretin-synthesizing and hypocretin-1 receptor-expressing neurons: effects of diurnal and nocturnal spontaneous waking, stress and hypocretin-1 administration
Highly Cited
2002
Highly Cited
2002
Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain
Highly Cited
2001
Highly Cited
2001
Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus
Highly Cited
2001
Highly Cited
2001
Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis.
The hypothalamic peptides, orexin-A and orexin-B, have been implicated in the regulation of feeding behavior. In starved rats… 
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