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orexins

Known as: Orexins [Chemical/Ingredient], Hypocretins, hypocretin 
Neuropeptide hormones that play a role in regulating a variety of behavioral and physiological processes in response to motivational stimuli.
National Institutes of Health

Related topics

Related topics

16 relations
HCRT geneHypothalamic HormonesIn BloodProcess of secretion
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Narrower (3)

HCRT protein, humanorexin Aorexin B

Broader (1)

Neuropeptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
To eat or to sleep: That is a lateral hypothalamic question
The lateral hypothalamus (LH) is a functionally and anatomically complex brain region that is involved in the regulation of many… Expand
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Review
2018
Review
2018
The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases
Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing neurons, mainly in the lateral… Expand
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Review
2018
Review
2018
Layer- and Cell Type-Specific Modulation of Excitatory Neuronal Activity in the Neocortex
From an anatomical point of view the neocortex is subdivided into up to six layers depending on the cortical area. This… Expand
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Highly Cited
2000
Highly Cited
2000
Hypocretin (orexin) deficiency in human narcolepsy
Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models. Hypocretin was… Expand
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Highly Cited
1999
Highly Cited
1999
Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation
Neurons containing the neuropeptide orexin (hypocretin) are located exclusively in the lateral hypothalamus and send axons to… Expand
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Highly Cited
1999
Highly Cited
1999
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
Narcolepsy is a disabling sleep disorder affecting humans and animals. It is characterized by daytime sleepiness, cataplexy, and… Expand
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Highly Cited
1998
Highly Cited
1998
Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel… Expand
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Highly Cited
1998
Highly Cited
1998
Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
The novel neuropeptides called hypocretins (orexins) have recently been identified as being localized exclusively in cell bodies… Expand
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Highly Cited
1998
Highly Cited
1998
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.
We describe a hypothalamus-specific mRNA that encodes preprohypocretin, the putative precursor of a pair of peptides that share… Expand
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Highly Cited
1998
Highly Cited
1998
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
 
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