orexins

Known as: Orexins [Chemical/Ingredient], Hypocretins, hypocretin 
Neuropeptide hormones that play a role in regulating a variety of behavioral and physiological processes in response to motivational stimuli.
National Institutes of Health

Related topics

Related topics

16 relations
HCRT geneHypothalamic HormonesIn BloodProcess of secretion
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Narrower (3)

HCRT protein, humanorexin Aorexin B

Broader (1)

Neuropeptides

Papers overview

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Review
2007
Review
2007
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
Sleep and wakefulness are regulated to occur at appropriate times that are in accordance with our internal and external… (More)
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Highly Cited
2005
Highly Cited
2005
A role for lateral hypothalamic orexin neurons in reward seeking
The lateral hypothalamus is a brain region historically implicated in reward and motivation, but the identity of the… (More)
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Highly Cited
2001
Highly Cited
2001
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Orexins (hypocretins) are a pair of neuropeptides implicated in energy homeostasis and arousal. Recent reports suggest that loss… (More)
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Highly Cited
2001
Highly Cited
2001
Differential expression of orexin receptors 1 and 2 in the rat brain.
Orexins (hypocretins) are neuropeptides synthesized in the central nervous system exclusively by neurons of the lateral… (More)
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Highly Cited
1999
Highly Cited
1999
Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation
Neurons containing the neuropeptide orexin (hypocretin) are located exclusively in the lateral hypothalamus and send axons to… (More)
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Highly Cited
1999
Highly Cited
1999
Orexin A activates locus coeruleus cell firing and increases arousal in the rat.
The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The… (More)
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Highly Cited
1999
Highly Cited
1999
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.
We determined the immunohistochemical distributions of orexin-A and orexin-B, hypothalamic peptides that function in the… (More)
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Highly Cited
1999
Highly Cited
1999
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
Narcolepsy is a disabling sleep disorder affecting humans and animals. It is characterized by daytime sleepiness, cataplexy, and… (More)
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Highly Cited
1998
Highly Cited
1998
Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel… (More)
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Highly Cited
1998
Highly Cited
1998
Neurons containing hypocretin (orexin) project to multiple neuronal systems.
The novel neuropeptides called hypocretins (orexins) have recently been identified as being localized exclusively in cell bodies… (More)
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