Gut hormone PYY3-36 physiologically inhibits food intake
Peripheral injection of PYY3-36 in rats inhibits food intake and reduces weight gain and suggests that the anorectic effect requires the Y2R, a putative inhibitory presynaptic receptor in the arcuate nucleus of the hypothalamus.
Inhibition of food intake in obese subjects by peptide YY3-36.
- R. Batterham, Mark A Cohen, S. Bloom
- Medicine, BiologyNew England Journal of Medicine
- 4 September 2003
It is found that obese subjects were not resistant to the anorectic effects of PYY, and endogenous PYY levels were low in obese subjects, suggesting that PYY deficiency may contribute to the pathogenesis of obesity.
A role for glucagon-like peptide-1 in the central regulation of feeding
It is reported here that intracerebroventricular (ICV) GLP-1 powerfully inhibits feeding in fasted rats, and this findings suggest that central GLp-1 is a new physiological mediator of satiety.
GLUCAGON-LIKE PEPTIDE-1 7-36: A PHYSIOLOGICAL INCRETIN IN MAN
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
- Graham M Lord, G. Matarese, J. K. Howard, R. Baker, S. Bloom, R. Lechler
- Biology, MedicineNature
- 27 August 1998
It is reported here that leptin has a specific effect on T-lymphocyte responses, differentially regulating the proliferation of naive and memory T cells, and suggesting a new role for leptin in linking nutritional status to cognate cellular immune function.
Ghrelin enhances appetite and increases food intake in humans.
- A. Wren, L. Seal, S. Bloom
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 December 2001
Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man and is a potentially important new regulator of the complex systems controlling food intake and body weight.
Ghrelin causes hyperphagia and obesity in rats.
Evidence is provided that ghrelin is important in long-term control of food intake and body weight and that circulating gh Relin at fasting concentrations may stimulate food intake.
Human distribution and release of a putative new gut hormone, peptide YY.
Gut hormones and the regulation of energy homeostasis
New research suggests that gut hormones can be used to specifically regulate energy homeostasis in humans, and offer a target for anti-obesity drugs.
The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.
It is found that both intracerebroventricular and intraperitoneal administration of ghrelin in freely feeding rats stimulated food intake and plasma growth hormone (GH) concentration increased following both i.c.v. and i.p. administration.