S. Bloom

Publications2,304
h-index159
Citations116,413
Highly Influential Citations3,174
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Gut hormone PYY3-36 physiologically inhibits food intake
TLDR
Peripheral injection of PYY3-36 in rats inhibits food intake and reduces weight gain and suggests that the anorectic effect requires the Y2R, a putative inhibitory presynaptic receptor in the arcuate nucleus of the hypothalamus. Expand
Inhibition of food intake in obese subjects by peptide YY3-36.
TLDR
It is found that obese subjects were not resistant to the anorectic effects of PYY, and endogenous PYY levels were low in obese subjects, suggesting that PYY deficiency may contribute to the pathogenesis of obesity. Expand
A role for glucagon-like peptide-1 in the central regulation of feeding
TLDR
It is reported here that intracerebroventricular (ICV) GLP-1 powerfully inhibits feeding in fasted rats, and this findings suggest that central GLp-1 is a new physiological mediator of satiety. Expand
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
TLDR
It is reported here that leptin has a specific effect on T-lymphocyte responses, differentially regulating the proliferation of naive and memory T cells, and suggesting a new role for leptin in linking nutritional status to cognate cellular immune function. Expand
GLUCAGON-LIKE PEPTIDE-1 7-36: A PHYSIOLOGICAL INCRETIN IN MAN
TLDR
The observation of greatly increased postprandial plasma GLP-1 7-36 levels in patients with postgastrectomy dumping syndrome suggests that it may mediate the hyperinsulinaemia and reactive hypoglycaemia of this disorder. Expand
Ghrelin enhances appetite and increases food intake in humans.
TLDR
Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man and is a potentially important new regulator of the complex systems controlling food intake and body weight. Expand
Ghrelin causes hyperphagia and obesity in rats.
TLDR
Evidence is provided that ghrelin is important in long-term control of food intake and body weight and that circulating gh Relin at fasting concentrations may stimulate food intake. Expand
Gut hormones and the regulation of energy homeostasis
TLDR
New research suggests that gut hormones can be used to specifically regulate energy homeostasis in humans, and offer a target for anti-obesity drugs. Expand
Human distribution and release of a putative new gut hormone, peptide YY.
TLDR
The known potent biologic actions of PYY, its high concentrations in gut endocrine cells, and its release into the circulation after a normal meal suggest that this peptide may function physiologically as a circulating gut hormone. Expand
AMP-activated Protein Kinase Plays a Role in the Control of Food Intake*
TLDR
It is demonstrated that counter-regulatory hormones involved in appetite control regulate AMPK activity and that pharmacological activation of AMPK in the hypothalamus increases food intake, and that AMPK is identified as a novel target for anti-obesity drugs. Expand
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