• Publications
  • Influence
Clues to the functions of mammalian sleep
  • J. Siegel
  • Biology, Psychology
    Nature
  • 26 October 2005
The functions of mammalian sleep remain unclear. Most theories suggest a role for non-rapid eye movement (NREM) sleep in energy conservation and in nervous system recuperation. Theories of REM sleep
Sleep
TLDR
Evidence for a role of non-REM sleep in developmental central nervous system (CNS) plasticity, as well as learning and memory, is discussed and a link with complex metabolic processes is suggested.
Do all animals sleep?
  • J. Siegel
  • Biology, Psychology
    Trends in Neurosciences
  • 1 April 2008
Hypocretin (orexin) cell loss in Parkinson’s disease
TLDR
It is found that Parkinson’s disease is characterized by a massive loss of Hcrt neurons, which may be a cause of the narcolepsy-like symptoms of PD and may be ameliorated by treatments aimed at reversing the HCRt deficit.
The REM Sleep-Memory Consolidation Hypothesis
  • J. Siegel
  • Psychology, Biology
    Science
  • 2 November 2001
TLDR
The evidence for the hypothesis that REM (rapid eye movement) sleep has an important role in memory consolidation is reviewed and found to be weak and contradictory.
Cetacean sleep: An unusual form of mammalian sleep
Sleep viewed as a state of adaptive inactivity
  • J. Siegel
  • Psychology
    Nature Reviews Neuroscience
  • 1 October 2009
TLDR
It is proposed that sleep is best understood as a variant of dormant states seen throughout the plant and animal kingdoms and that it is itself highly adaptive because it optimizes the timing and duration of behaviour.
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