J. Siegel

Publications339
h-index75
Citations20,077
Highly Influential Citations676
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Reduced Number of Hypocretin Neurons in Human Narcolepsy
View on Elsevier
Clues to the functions of mammalian sleep
  • J. Siegel
  • Biology, Psychology
    Nature
  • 26 October 2005
The functions of mammalian sleep remain unclear. Most theories suggest a role for non-rapid eye movement (NREM) sleep in energy conservation and in nervous system recuperation. Theories of REM sleep…
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Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons
View on Elsevier
Sleep
TLDR
Evidence for a role of non-REM sleep in developmental central nervous system (CNS) plasticity, as well as learning and memory, is discussed and a link with complex metabolic processes is suggested.
View on Springer
Do all animals sleep?
  • J. Siegel
  • Biology, Psychology
    Trends in Neurosciences
  • 1 April 2008
View on Elsevier
Hypocretin (orexin) cell loss in Parkinson’s disease
TLDR
It is found that Parkinson’s disease is characterized by a massive loss of Hcrt neurons, which may be a cause of the narcolepsy-like symptoms of PD and may be ameliorated by treatments aimed at reversing the HCRt deficit.
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Natural Sleep and Its Seasonal Variations in Three Pre-industrial Societies
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The REM Sleep-Memory Consolidation Hypothesis
  • J. Siegel
  • Psychology, Biology
    Science
  • 2 November 2001
TLDR
The evidence for the hypothesis that REM (rapid eye movement) sleep has an important role in memory consolidation is reviewed and found to be weak and contradictory.
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Cetacean sleep: An unusual form of mammalian sleep
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Sleep viewed as a state of adaptive inactivity
  • J. Siegel
  • Psychology
    Nature Reviews Neuroscience
  • 1 October 2009
TLDR
It is proposed that sleep is best understood as a variant of dormant states seen throughout the plant and animal kingdoms and that it is itself highly adaptive because it optimizes the timing and duration of behaviour.
View on Nature
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