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Pharmacological analysis of male rat sexual behavior
  • D. Bitrán, E. Hull
  • Biology, Medicine
  • Neuroscience & Biobehavioral Reviews
  • 1 December 1987
Evidence is presented that serotonergic influence is generally inhibitory to sexual behavior, although two receptor subtypes may lower ejaculation threshold and ACTH and MSH peptides promote copulatory behavior and genital responses. Expand
Sexual behavior in male rodents
Hormonal activation of the medial preoptic area (MPOA) is most effective, although implants in the medial amygdala (MeA) can also stimulate mounting in castrates. Expand
Dopamine and serotonin: influences on male sexual behavior
Steroid hormones regulate sexual behavior primarily by slow, genomically mediated effects by enhancing the processing of relevant sensory stimuli, altering the synthesis, release, and/or receptors for neurotransmitters in integrative areas, and increasing the responsiveness of appropriate motor outputs. Expand
Dopamine, the medial preoptic area, and male sexual behavior
Data indicating that the medial preoptic area (MPOA) is one site where DA may act to regulate male sexual behavior is reviewed, indicating that DA agonists microinjected into the MPOA facilitate sexual behavior, whereas DA antagonists impair copulation, genital reflexes, and sexual motivation. Expand
Sex differences in anxiety and depression: Role of testosterone
While the precise underlying mechanisms remain unclear, both activational and organizational effects of testosterone appear to contribute to these effects, and possible neurobiological mechanisms underlying testosterone's mostly protective benefits are presented. Expand
Hormone-neurotransmitter interactions in the control of sexual behavior
R reciprocal changes in DA and 5-HT release in different areas of the brain may promote copulation and sexual satiety, respectively. Expand
A Role for Hypocretin (Orexin) in Male Sexual Behavior
The view that hcrt/orx peptides may act in a steroid-sensitive manner to facilitate the energized pursuit of natural rewards like sex via activation of the mesolimbic DA system is supported. Expand
Male Sexual Behavior
Major areas controlling sexual motivation and performance in males include the mesolimbic dopamine (DA) system, the medial preoptic area (MPOA), the amygdala, and the bed nucleus of the striaExpand
D2/D1 ratio in the medial preoptic area affects copulation of male rats.
Increasing the D2/D1 ratio in the MPOA, by selective stimulation of D2 and/or antagonism of D1 receptors, delays the onset of copulation and reduces ejaculatory threshold, possibly by altering autonomic control of penile reflexes. Expand
Getting his act together: Roles of glutamate, nitric oxide, and dopamine in the medial preoptic area
Glutamate, NO, and dopamine interact in the medial preoptic area of male rats to facilitate mating and to enhance future sexual responsiveness. Expand