FAQ

Genetic Heterogeneity

Known as: Heterogeneities, Genetic, Genetic Heterogeneities, Heterogeneous. 
The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1940-2017
0500100019402016

Related topics

Related topics

50 relations
AMYOTROPHIC LATERAL SCLEROSIS 1AXENFELD-RIEGER SYNDROME, TYPE 3Albinism with hemorrhagic diathesis and pigmented reticuloendothelial cellsAlport Syndrome, X-Linked
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Genetic Heterogeneity
Liver carcinoma
Alzheimer's Disease
Schizophrenia
Malignant neoplasm of breast
Nephroblastoma

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Cell-free circulating tumour DNA as a liquid biopsy in breast cancer.
Recent developments in massively parallel sequencing and digital genomic techniques support the clinical validity of cell-free… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Review
2015
Review
2015
Breast cancer intrinsic subtype classification, clinical use and future trends.
Breast cancer is composed of multiple subtypes with distinct morphologies and clinical implications. The advent of microarrays… (More)
  • table 1
  • figure 1
  • figure 2
  • table 2
Is this relevant?
Review
2015
Review
2015
Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity
Tumor cells able to recapitulate tumor heterogeneity have been tracked, isolated and characterized in different tumor types, and… (More)
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Genetic heterogeneity and cancer drug resistance.
Despite the success of targeted therapies in the treatment of cancer, the development of resistance limits the ability to… (More)
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Genetic Heterogeneity in Human Disease
Strong evidence suggests that rare mutations of severe effect are responsible for a substantial portion of complex human disease… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases.
PURPOSE Epidermal growth factor receptor (EGFR) antibody therapy is established in patients with wild-type KRAS colorectal… (More)
  • table 1
  • table 2
  • figure 1
  • table 3
  • figure 2
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Genetic heterogeneity in HER2 testing in breast cancer: panel summary and guidelines.
CONTEXT Intratumoral heterogeneity of HER2 gene amplification has been well documented and represents subclonal diversity within… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity.
The identification and characterization of genes that influence the risk of common, complex multifactorial diseases, primarily… (More)
  • figure 1
  • figure 2
  • table I
  • table II
Is this relevant?
Highly Cited
2002
Highly Cited
2002
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of…
OBJECTIVE Neonatal-onset multisystem inflammatory disease (NOMID; also known as chronic infantile neurologic, cutaneous… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.
Breast cancer is known to have an inherited component, consistent in some families with autosomal dominant inheritance; in such… (More)
Is this relevant?