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Continuous cultures of fused cells secreting antibody of predefined specificity
TLDR
The derivation of a number of tissue culture cell lines which secrete anti-sheep red blood cell (SRBC) antibodies is described here, made by fusion of a mouse myeloma and mouse spleen cells from an immunised donor. Expand
Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis
TLDR
The experiments established the usefulness of the bybrid myeloma technique in preparing monospecific antibodies against human cell surface antigens and highlights the possibilities not only of obtaining reagents for somatic cell genetics, but also of obtaining mouse antibodies detecting human antigenic polymorphisms. Expand
Mac‐1: a macrophage differentiation antigen identified by monoclonal antibody
TLDR
M1/70 thus defines a differentiation antigen on mononuclear phagocytes and granulocytes, the expression of which is specifically increased during monocyte maturation, the first to be described which recognizes a discrete molecule specific to phagocyte. Expand
Derivation of specific antibody‐producing tissue culture and tumor lines by cell fusion
TLDR
Cell fusion techniques have been used to produce hybrids between myeloma cells and antibody‐producing cells that are permanently adapted to grow in tissue culture and are capable of inducing antibody-producing tumors in mice. Expand
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.
TLDR
A substantially enriched preparation of Alzheimer paired helical filaments has been used as a starting point for biochemical studies and sequence analysis of these peptides was used to design oligonucleotide probes for cloning a cognate cDNA, which leads to its identification as human microtubule-associated tau protein. Expand
Mutation Drift and Repertoire Shift in the Maturation of the Immune Response
TLDR
The halltnark of the immune response is its specificity and the specificity is directly correlated with the affinity of the antigen-antibody interaction, which means that T cells may not have developed the equivalent of the elaborate mechanism which is the object of this paper. Expand
Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51.
TLDR
It is concluded that 423 reactivity also requires a modification(s) occurring within an approximately 90-residue segment that are not present in tau proteins so far described in the human brain. Expand
Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens
TLDR
Hybrid myeloma cell lines secreting monoclonal antibodies to mouse cell surface antigens have been prepared and each antigenic target was analyzed by gel electrophoresis of immunoprecipitated 125I‐labeled cell surface molecules. Expand
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting.
TLDR
It is suggested that MSH2 (or factors dependent upon it) plays a role in the mechanism of mutation fixation is indicated by a strikingly increased focusing of the mutations on intrinsic hot spots, and two phases to hypermutation targeting are proposed. Expand
Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region
TLDR
The results show that full hypermutation depends on multiple elements, removal of some of which may drastically impair but not totally abolish the process. Expand
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