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Migration patterns and breast cancer risk in Asian-American women.
Exposure to Western lifestyles had a substantial impact on breast cancer risk in Asian migrants to the United States during their lifetime, and this study should provide new insights into the etiology of breast cancer.
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
Efficient methods of analysis of randomized clinical trials in which the authors wish to compare the duration of survival among different groups of patients are described.
A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics.
As expected, both within and among ethnic groups, the questionnaire data show substantial variations in dietary intakes and in the distributions of non-dietary risk factors (including smoking, alcohol consumption, obesity, and physical activity).
Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin.
This study provides strong evidence that the addition of a progestin to HRT enhances markedly the risk of breast cancer relative to estrogen use alone, and has important implications for the risk-benefit equation for HRT in women using CHRT.
Calibration of the dietary questionnaire for a multiethnic cohort in Hawaii and Los Angeles.
The performance of the dietary questionnaire used in a multiethnic cohort study in Hawaii and Los Angeles was assessed in a calibration substudy that compared diet reported from the questionnaire
Multiple regions within 8q24 independently affect risk for prostate cancer
Seven prostate cancer risk variants are identified, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 × 10−19 for the strongest association), and common genotypes that span a more than fivefold range of susceptibility to cancer in some populations are defined.
Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies
Clinicians should be aware of the increased risk of specific subtypes of ovarian cancer in women with endometriosis, and future efforts should focus on understanding the mechanisms that might lead to malignant transformation of endometRIosis so as to help identify subsets of women at increased riskof ovarian cancer.
Choosing Haplotype-Tagging SNPS Based on Unphased Genotype Data Using a Preliminary Sample of Unrelated Subjects with an Example from the Multiethnic Cohort Study
We describe an approach for picking haplotype-tagging single nucleotide polymorphisms (htSNPs) that is presently being taken in two large nested case-control studies within a multiethnic cohort
A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase.
One amino acid substitution is reported, V89L, which replaces valine at codon 89 with leucine, and it is common, panethnic, and reduces in vivo steroid 5alpha-reductase activity, which may explain the low risk for prostate cancer in this population.