Genes, abl

Known as: Gene, abl, abl Gene, abl Genes 
Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1982-2018
051019822018

Papers overview

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Highly Cited
2003
Highly Cited
2003
Small interfering RNAs (siRNAs) were designed to target the bcr-abl oncogene, which causes chronic myeloid leukemia (CML) and bcr… (More)
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Highly Cited
2002
Highly Cited
2002
The inadvertent fusion of the bcr gene with the abl gene results in a constitutively active tyrosine kinase (Bcr-Abl) that… (More)
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Highly Cited
1998
Highly Cited
1998
Bcr-Abl expression in leukemic cells is known to exert a potent effect against apoptosis due to antileukemic drugs, but its… (More)
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Highly Cited
1996
Highly Cited
1996
THE c-Abl protein tyrosine kinase is activated by certain DNA-damaging agents1, and its overexpression causes arrest in the G1… (More)
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Highly Cited
1991
Highly Cited
1991
Chronic myelogenous leukemia and one type of acute lymphoblastic leukemia are characterized by a 9;22 chronosome translocation in… (More)
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Highly Cited
1990
Highly Cited
1990
The chromosome translocation forming the hybrid bcr-abl gene is thought to be the initiating event in chronic myeloid leukaemia… (More)
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Highly Cited
1990
Highly Cited
1990
Chronic myelogeneous leukemia (CML) is genetically characterized by fusion of the bcr and abl genes on chromosomes 22 and 9… (More)
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Highly Cited
1987
Highly Cited
1987
The Philadelphia (Ph) chromosome, the product of t(9:22), is the cytogenetic hallmark of chronic myelogenous leukemia. The c-abl… (More)
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Highly Cited
1987
Highly Cited
1987
In the Philadelphia chromosome (Ph1) of chronic myelogenous leukemia (CML), the c-abl gene on chromosome 9 is translocated to bcr… (More)
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Highly Cited
1986
Highly Cited
1986
The primary structure of normal abl protein was determined by sequencing the coding region of its cDNA. abl contains two… (More)
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