FAQ

Genes, abl

Known as: Gene, abl, abl Gene, abl Genes 
Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1982-2018
051019822018

Related topics

Related topics

6 relations
Fusion Proteins, bcr-ablOncogene Proteins v-ablProto-Oncogene Proteins c-ablphysiological aspects

Narrower (2)

abl Oncogenec-abl Proto-Oncogenes

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Genes, abl
physiological aspects
Fusion Proteins, bcr-abl
abl Oncogene
Proto-Oncogene Proteins c-abl
Oncogene Proteins v-abl

Papers overview

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Highly Cited
2003
Highly Cited
2003
Specific inhibition of bcr-abl gene expression by small interfering RNA.
Small interfering RNAs (siRNAs) were designed to target the bcr-abl oncogene, which causes chronic myeloid leukemia (CML) and bcr… (More)
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Highly Cited
2002
Highly Cited
2002
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).
The inadvertent fusion of the bcr gene with the abl gene results in a constitutively active tyrosine kinase (Bcr-Abl) that… (More)
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Highly Cited
1998
Highly Cited
1998
Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3.
Bcr-Abl expression in leukemic cells is known to exert a potent effect against apoptosis due to antileukemic drugs, but its… (More)
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Highly Cited
1996
Highly Cited
1996
Role for c-Abl tyrosine kinase in growth arrest response to DNA damage
THE c-Abl protein tyrosine kinase is activated by certain DNA-damaging agents1, and its overexpression causes arrest in the G1… (More)
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Highly Cited
1991
Highly Cited
1991
Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins.
Chronic myelogenous leukemia and one type of acute lymphoblastic leukemia are characterized by a 9;22 chronosome translocation in… (More)
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Highly Cited
1990
Highly Cited
1990
bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.
The chromosome translocation forming the hybrid bcr-abl gene is thought to be the initiating event in chronic myeloid leukaemia… (More)
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Highly Cited
1990
Highly Cited
1990
Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization.
Chronic myelogeneous leukemia (CML) is genetically characterized by fusion of the bcr and abl genes on chromosomes 22 and 9… (More)
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Highly Cited
1987
Highly Cited
1987
Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia.
The Philadelphia (Ph) chromosome, the product of t(9:22), is the cytogenetic hallmark of chronic myelogenous leukemia. The c-abl… (More)
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Highly Cited
1987
Highly Cited
1987
Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL.
In the Philadelphia chromosome (Ph1) of chronic myelogenous leukemia (CML), the c-abl gene on chromosome 9 is translocated to bcr… (More)
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Highly Cited
1986
Highly Cited
1986
Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene.
The primary structure of normal abl protein was determined by sequencing the coding region of its cDNA. abl contains two… (More)
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