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Genes, abl

Known as: Gene, abl, abl Gene, abl Genes 
Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes… Expand
National Institutes of Health

Related topics

Related topics

7 relations
Fusion Proteins, bcr-ablOncogene Proteins v-ablProto-Oncogene Proteins c-ablaspects of radiation effects
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Narrower (2)

abl Oncogenec-abl Proto-Oncogenes

Papers overview

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Highly Cited
2003
Highly Cited
2003
Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells.
Present studies demonstrate that treatment with arsenic trioxide (AT) lowered ectopically expressed or endogenous levels of Bcr… Expand
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Highly Cited
1999
Highly Cited
1999
Inhibition of bcr-abl oncogene expression by novel deoxyribozymes (DNAzymes).
Deoxyribozymes, or DNA enzymes (DNAzymes), are novel nucleic acids that have the ability to bind to specific sequences of RNA… Expand
Highly Cited
1991
Highly Cited
1991
Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins.
Chronic myelogenous leukemia and one type of acute lymphoblastic leukemia are characterized by a 9;22 chronosome translocation in… Expand
Highly Cited
1990
Highly Cited
1990
Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization
Chronic myelogeneous leukemia (CML) is genetically characterized by fusion of the bcr and abl genes on chromosomes 22 and 9… Expand
Highly Cited
1988
Highly Cited
1988
Detection of minimal residual bcr/abl transcripts by a modified polymerase chain reaction.
The Philadelphia (Ph1) chromosome in chronic myelogenous leukemia (CML) involves reciprocal translocation of the bcr gene and the… Expand
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Highly Cited
1987
Highly Cited
1987
Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia
The Philadelphia (Ph) chromosome, the product of t(9:22), is the cytogenetic hallmark of chronic myelogenous leukemia. The c-abl… Expand
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Highly Cited
1987
Highly Cited
1987
The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia.
The c-abl protooncogene is unusual in two respects; it has multiple, widely space N-terminal coding exons transcribed by… Expand
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Highly Cited
1987
Highly Cited
1987
Molecular characterization of the testis specific c‐abl mRNA in mouse.
The c‐abl gene encodes a protein tyrosine kinase and is transcribed from at least two promoters giving rise to transcripts of two… Expand
Highly Cited
1986
Highly Cited
1986
Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene
The primary structure of normal abl protein was determined by sequencing the coding region of its cDNA. abl contains two… Expand
Highly Cited
1984
Highly Cited
1984
The mouse c-abl locus: Molecular cloning and characterization
The mouse c-abl gene, part of the sequence of which was captured in Moloney murine leukemia virus to generate the transforming… Expand
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