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abl Oncogene

Known as: Oncogene, v-abl, v-abl Gene, v abl 
Human v-abl Abelson murine leukemia viral oncogene homolog 1 (ABL1) gene, located at 9q34.1, encodes proto-oncogene tyrosine-protein kinase ABL1… Expand
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
Resistance to the ABL kinase inhibitor imatinib (STI571 or Gleevec) in chronic myeloid leukemia (CML) occurs through selection… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND BCR-ABL is a constitutively activated tyrosine kinase that causes chronic myeloid leukemia (CML). Since tyrosine… Expand
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Highly Cited
2001
Highly Cited
2001
Clinical studies with the Abl tyrosine kinase inhibitor STI-571 in chronic myeloid leukemia demonstrate that many patients with… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND BCR-ABL, a constitutively activated tyrosine kinase, is the product of the Philadelphia chromosome. This enzyme is… Expand
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Highly Cited
1993
Highly Cited
1993
A phosphopeptide library was used to determine the sequence specificity of the peptide-binding sites of SH2 domains. One group of… Expand
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Highly Cited
1990
Highly Cited
1990
Oncogenic activation of the proto-oncogene c-abl in human leukemias occurs as a result of the addition of exons from the gene bcr… Expand
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Highly Cited
1984
Highly Cited
1984
The v-abl protein is known to be a tyrosine-specific protein kinase. However, its normal cellular homolog, c-abl P150, is not… Expand
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Highly Cited
1983
Highly Cited
1983
The human c-abl oncogene maps within the region (q34-qter) of chromosome 9 which is translocated to chromosome 22, the… Expand
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Highly Cited
1983
Highly Cited
1983
The localization of cellular oncogenes near the break points of tumour-specific chromosomal aberrations suggests an involvement… Expand
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Highly Cited
1982
Highly Cited
1982
The transforming genes of oncogenic retroviruses are homologous to a group of evolutionary conserved cellular onc genes1. The… Expand
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