abl Oncogene

Known as: Oncogene, v-abl, v-abl Gene, v abl 
Human v-abl Abelson murine leukemia viral oncogene homolog 1 (ABL1) gene, located at 9q34.1, encodes proto-oncogene tyrosine-protein kinase ABL1… (More)
National Institutes of Health

Papers overview

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Review
2005
Review
2005
Imatinib, a potent inhibitor of the oncogenic tyrosine kinase BCR–ABL, has shown remarkable clinical activity in patients with… (More)
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Highly Cited
2004
Highly Cited
2004
Resistance to the ABL kinase inhibitor imatinib (STI571 or Gleevec) in chronic myeloid leukemia (CML) occurs through selection… (More)
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Highly Cited
2001
Highly Cited
2001
Clinical studies with the Abl tyrosine kinase inhibitor STI-571 in chronic myeloid leukemia demonstrate that many patients with… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND BCR-ABL is a constitutively activated tyrosine kinase that causes chronic myeloid leukemia (CML). Since tyrosine… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND BCR-ABL, a constitutively activated tyrosine kinase, is the product of the Philadelphia chromosome. This enzyme is… (More)
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Highly Cited
2000
Highly Cited
2000
STI571 (formerly known as CGP 57148B) is a protein-tyrosine kinase inhibitor that is currently in clinical trials for the… (More)
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Highly Cited
2000
Highly Cited
2000
Targeting the tyrosine kinase activity of Bcr-Abl with STI571 is an attractive therapeutic strategy in chronic myelogenous… (More)
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Highly Cited
1999
Highly Cited
1999
The product of the Philadelphia chromosome (Ph) translocation, the BCR/ABL oncogene, exists in three principal forms (P190, P210… (More)
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Highly Cited
1999
Highly Cited
1999
Cancer chemotherapeutic agents such as cisplatin exert their cytotoxic effect by inducing DNA damage and activating programmed… (More)
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Highly Cited
1996
Highly Cited
1996
Oncogenic activation of Abl proteins due to structural modifications can occur as a result of viral transduction or chromosomal… (More)
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