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The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers
A 200-300 kb region of chromosome 3p14.2, including the fragile site locus FRA3B, is homozygously deleted in multiple tumor-derived cell lines, allowing identification of the human FHIT gene, a member of ther histidine triad gene family, which encodes a protein with 69% similarity to an S. pombe enzyme. Expand
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
The enforced expression of miR-29s in lung cancer cell lines restores normal patterns of DNA methylation, induces reexpression of methylation-silenced tumor suppressor genes, and inhibits tumorigenicity in vitro and in vivo. Expand
Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice.
Results indicate that altered expression of the homeobox gene Meis1 may be one of the events that lead to tumor formation in BXH-2 mice. Expand
Cloning and characterization of two members of the vertebrate Dlx gene family.
The expression pattern of these genes, together with their chromosome localization, may provide useful cues for the study of congenital disorders in which there is a combination of craniofacial and limb defects. Expand
Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA
To pinpoint critical cellular functions affected in the invasive transition, the protein coding genes with inversely related profiles to miR-210 were identified: BRCA1, FANCD, FANCF, PARP1, E-cadherin, and Rb1 were all activated in the in situ and down-regulated in thevasive carcinoma. Expand
Molecular cloning of a new transforming gene from a chemically transformed human cell line
Molecular cloning of the transforming gene from a chemically transformed human osteosarcoma-derived cell line enables the gene to be mapped to chromosome 7 (7p11.4–7qter) and by this criterion and byExpand
Cloning, Characterization, and Chromosomal Localization of a Human 5‐HT6 Serotonin Receptor
  • R. Kohen, Mark A. Metcalf, +7 authors M. Hamblin
  • Biology, Medicine
  • Journal of neurochemistry
  • 1 January 1996
Comparison of genomic and cDNA clones for the human 5‐HT6 receptor reveals an RsaI restriction fragment length polymorphism within the coding region, suggesting that these may be closely linked. Expand
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase.
Human Fhit (fragile histidine triad) protein is the first HIT protein in which the histidine residues have been demonstrated by mutagenesis to be critical for function, and the first evidence for a connection between dinucleotide oligophosphate metabolism and tumorigenesis is shown. Expand
Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation.
The cloning and the characterization of the partner gene from chromosome 6 (AF-6), which is expressed in a variety of cell types and encodes a protein of 1612 amino acids, contains the GLGF motif shared with several proteins of vertebrates and invertebrates thought to be involved in signal transduction at special cell-cell junctions. Expand
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.
Two overlapping cDNA clones encoding human DNA topoisomerase II were identified by two independent methods and hybridization between the cloned sequences and mRNA and genomic DNA indicates that the human enzyme is encoded by a single-copy gene. Expand