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GZMB protein, human

Known as: Granzyme 2, C11, SECT 
Granzyme B (247 aa, ~28 kDa) is encoded by the human GZMB gene. This protein plays a role in the mediation of cell-dependent cytotoxicity.
National Institutes of Health

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2014
2014
The crucial issue for defining successful natural killer (NK)-based anticancer therapy is the ability of tumor cells to activate… Expand
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Highly Cited
2008
Highly Cited
2008
The killer lymphocyte protease granzyme A (GzmA) triggers caspase-independent target cell death with morphological features of… Expand
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Highly Cited
2003
Highly Cited
2003
The cytolytic T lymphocyte protease granzyme A (GzmA) initiates a caspase-independent cell death pathway. Here we report that the… Expand
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1996
1996
Cytotoxic T and natural killer cells are able to kill their target cells through synergistic action of the pore-forming protein… Expand
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1995
1995
B7-CD28 costimulation is essential for the activation of CD4+ T helper cells, mainly by regulating IL-2 and other cytokine… Expand
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Highly Cited
1992
Highly Cited
1992
We report the purification from a rat natural killer (RNK) large granular lymphocyte leukemia of a 32-kD granule protein that… Expand
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Highly Cited
1992
Highly Cited
1992
We recently reported the purification of a lymphocyte granule protein called "fragmentin," which was identified as a serine… Expand
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1988
1988
Human peripheral blood mononuclear cells, activated for 14 to 20 days with 1000 U/ml rIL-2, develop strong cytotoxicity for NK… Expand
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1988
1988
A human CD8+ CTL clone with cytolytic potential was shown to express two serine proteases, a 50-kDa homodimer and a 27-kDa… Expand
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1988
1988
T-lymphocytes contain a cytoplasmic granule associated homo-dimeric protease designated granzyme A. Upon T-cell target cell… Expand
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