Skip to search formSkip to main contentSkip to account menu

GZMB protein, human

Known as: Granzyme 2, C11, SECT 
Granzyme B (247 aa, ~28 kDa) is encoded by the human GZMB gene. This protein plays a role in the mediation of cell-dependent cytotoxicity.
National Institutes of Health

Related topics

Related topics

14 relations
Caspase Cascade PathwayCell-Mediated CytolysisCytotoxic T-LymphocytesEnzyme Gene

Broader (2)

Granzymesgranzyme B

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis
Cytotoxic lymphocyte protease granzyme M (GrM) is a potent inducer of tumor cell death. The apoptotic phenotype and mechanism by… 
Highly Cited
2006
Highly Cited
2006
The Cytotoxic Lymphocyte Protease, Granzyme B, Targets the Cytoskeleton and Perturbs Microtubule Polymerization Dynamics*
Granzyme B, a serine protease derived from cytotoxic T lymphocyte (CTL) and Natural Killer (NK) cell granules, plays an important… 
2004
2004
Proximity of the CTLA-1 serine esterase and Tcrα loci in mouse and man
The serine esterase CTLA-1 gene was shown by in situ hybridization to map to the D segment of mouse chromosome 14, the same… 
1999
1999
Acquired lipoprotein lipase deficiency associated with chronic urticaria. A new etiology for type I hyperlipoproteinemia.
Type I hyperlipoproteinemia (type I HLP) is a rare disorder of lipid metabolism characterized by fasting chylomicronemia and… 
Highly Cited
1995
Highly Cited
1995
B7 costimulation is necessary for the activation of the lytic function in cytotoxic T lymphocyte precursors.
B7-CD28 costimulation is essential for the activation of CD4+ T helper cells, mainly by regulating IL-2 and other cytokine… 
1993
1993
DNA fragmentation induced by cytotoxic T lymphocytes can result in target cell death.
Cytotoxic T lymphocyte (CTL)-mediated lysis is accompanied by fragmentation of target cell DNA into an oligonucleosome ladder, a… 
Highly Cited
1991
Highly Cited
1991
The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors.
To kill other cells, lymphocytes can exocytose granules that contain serine proteases and pore-forming proteins (perforins). We… 
1990
1990
An interspecific backcross linkage map of the proximal half of mouse chromosome 14.
Highly Cited
1988
Highly Cited
1988
Characterization of three serine esterases isolated from human IL-2 activated killer cells.
Human peripheral blood mononuclear cells, activated for 14 to 20 days with 1000 U/ml rIL-2, develop strong cytotoxicity for NK… 
Review
1987
Review
1987
CTLA-1 and CTLA-3 serine esterase transcripts are detected mostly in cytotoxic T cells, but not only and not always.
We and other investigators previously reported the cloning of CTLA-1 (or CCP-1) and CTLA-3 (or H Factor) serine esterase-related… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)