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granzyme B

Known as: Cytotoxic T-Lymphocyte Associated 1 Protein, Granzyme Like Protein III, Cytotoxic Serine Protease B 
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Summary:  The caspase family of cysteine proteases becomes activated in response to diverse cellular insults and coordinates… 
Highly Cited
2006
Highly Cited
2006
Granzyme B is critical to the ability of natural killer cells and cytotoxic T lymphocytes to induce efficient cell death of… 
Highly Cited
2004
Highly Cited
2004
Objective—T cell-induced cytotoxicity, of which granzyme B is a key mediator, is believed to contribute to the pathogenesis of… 
Highly Cited
2001
Highly Cited
2001
Cytotoxic T lymphocytes kill virus-infected and tumor cell targets through the concerted action of proteins contained in… 
Highly Cited
2000
Highly Cited
2000
The essential upstream steps in granzyme B–mediated apoptosis remain undefined. Herein, we show that granzyme B triggers the… 
Highly Cited
1998
Highly Cited
1998
In the widely accepted model of granule-mediated killing by cytotoxic lymphocytes, granzyme B entry into the target cell is… 
Highly Cited
1996
Highly Cited
1996
Cytotoxic T and natural killer cells are able to kill their target cells through synergistic action of the pore-forming protein… 
Highly Cited
1996
Highly Cited
1996
Cytotoxic lymphocytes utilize granule associated serine proteases (granzymes) and perforin to induce apoptosis. Although the… 
Highly Cited
1993
Highly Cited
1993
Cartilage degradation, a hallmark of rheumatoid arthritis, is attributed to serine and metalloproteases secreted by neutrophils…