granzyme B

Known as: Cytotoxic T-Lymphocyte Associated 1 Protein, Granzyme Like Protein III, Cytotoxic Serine Protease B 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
051019902017

Papers overview

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2006
2006
Granzyme B is critical to the ability of natural killer cells and cytotoxic T lymphocytes to induce efficient cell death of… (More)
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2004
2004
OBJECTIVE T cell-induced cytotoxicity, of which granzyme B is a key mediator, is believed to contribute to the pathogenesis of… (More)
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Highly Cited
2003
Highly Cited
2003
Cytotoxic lymphocytes employ Granzyme B as a potent initiator of apoptosis to cleave and activate effector caspases. Unexpectedly… (More)
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Highly Cited
2003
Highly Cited
2003
Apoptosis in response to granzyme B involves activation of caspase-dependent target cell death pathways. Herein, we show that… (More)
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Highly Cited
2001
Highly Cited
2001
Cytotoxic T lymphocytes kill virus-infected and tumor cell targets through the concerted action of proteins contained in… (More)
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Highly Cited
2000
Highly Cited
2000
The essential upstream steps in granzyme B-mediated apoptosis remain undefined. Herein, we show that granzyme B triggers the… (More)
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Highly Cited
1998
Highly Cited
1998
In the widely accepted model of granule-mediated killing by cytotoxic lymphocytes, granzyme B entry into the target cell is… (More)
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Highly Cited
1998
Highly Cited
1998
Caspase-mediated proteolysis of downstream substrates is a critical element of the execution pathway common to all forms of… (More)
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1996
1996
Cytotoxic T and natural killer cells are able to kill their target cells through synergistic action of the pore-forming protein… (More)
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1993
1993
Cartilage degradation, a hallmark of rheumatoid arthritis, is attributed to serine and metalloproteases secreted by neutrophils… (More)
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