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granzyme B

Known as: Cytotoxic T-Lymphocyte Associated 1 Protein, Granzyme Like Protein III, Cytotoxic Serine Protease B 
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Summary:  The caspase family of cysteine proteases becomes activated in response to diverse cellular insults and coordinates… Expand
Highly Cited
2006
Highly Cited
2006
Granzyme B is critical to the ability of natural killer cells and cytotoxic T lymphocytes to induce efficient cell death of… Expand
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Highly Cited
2003
Highly Cited
2003
Cytotoxic lymphocytes employ Granzyme B as a potent initiator of apoptosis to cleave and activate effector caspases. Unexpectedly… Expand
Highly Cited
2003
Highly Cited
2003
Apoptosis in response to granzyme B involves activation of caspase-dependent target cell death pathways. Herein, we show that… Expand
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Highly Cited
2001
Highly Cited
2001
  • Michael J. Pinkoski, Nigel J. Waterhouse, +6 authors Douglas R. Green
  • The Journal of Biological Chemistry
  • 2001
  • Corpus ID: 2950021
Cytotoxic T lymphocytes kill virus-infected and tumor cell targets through the concerted action of proteins contained in… Expand
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Highly Cited
2000
Highly Cited
2000
The essential upstream steps in granzyme B–mediated apoptosis remain undefined. Herein, we show that granzyme B triggers the… Expand
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Highly Cited
1998
Highly Cited
1998
Caspase-mediated proteolysis of downstream substrates is a critical element of the execution pathway common to all forms of… Expand
Highly Cited
1998
Highly Cited
1998
In the widely accepted model of granule-mediated killing by cytotoxic lymphocytes, granzyme B entry into the target cell is… Expand
Highly Cited
1996
Highly Cited
1996
Cytotoxic T and natural killer cells are able to kill their target cells through synergistic action of the pore-forming protein… Expand
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Highly Cited
1993
Highly Cited
1993
Cartilage degradation, a hallmark of rheumatoid arthritis, is attributed to serine and metalloproteases secreted by neutrophils… Expand