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Summary: The caspase family of cysteine proteases becomes activated in response to diverse cellular insults and coordinates… Expand Granzyme B is critical to the ability of natural killer cells and cytotoxic T lymphocytes to induce efficient cell death of… Expand Cytotoxic lymphocytes employ Granzyme B as a potent initiator of apoptosis to cleave and activate effector caspases. Unexpectedly… Expand Apoptosis in response to granzyme B involves activation of caspase-dependent target cell death pathways. Herein, we show that… Expand Cytotoxic T lymphocytes kill virus-infected and tumor cell targets through the concerted action of proteins contained in… Expand The essential upstream steps in granzyme B–mediated apoptosis remain undefined. Herein, we show that granzyme B triggers the… Expand Caspase-mediated proteolysis of downstream substrates is a critical element of the execution pathway common to all forms of… Expand In the widely accepted model of granule-mediated killing by cytotoxic lymphocytes, granzyme B entry into the target cell is… Expand Cytotoxic T and natural killer cells are able to kill their target cells through synergistic action of the pore-forming protein… Expand Cartilage degradation, a hallmark of rheumatoid arthritis, is attributed to serine and metalloproteases secreted by neutrophils… Expand