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GZMB gene

Known as: GRANZYME 2, CSPB, SECT 
This gene plays a role in cell-mediated cytolysis.
National Institutes of Health

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7 relations
Cell-Mediated CytolysisGZMB protein, humanGZMH geneHydrolysis

Papers overview

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2019
2019
Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers
Purpose Although both anti-PD-1 antibody and treatments using anti-PD-L1 antibody are currently in clinical use, their… 
Highly Cited
2016
Highly Cited
2016
Cytotoxic T Cells and Granzyme B Associated with Improved Colorectal Cancer Survival in a Prospective Cohort of Older Women
Background: Host immune response may predict the course of colorectal cancer. We examined the survival of 468 colorectal cancer… 
2005
2005
Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes?
Polymorphonuclear leukocytes have been shown to use a multitude of effector functions to combat pathogens and tumors, including… 
1994
1994
Effect of pravastatin treatment on glucose, insulin, and lipoprotein metabolism in patients with hypercholesterolemia.
Highly Cited
1992
Highly Cited
1992
Perforin expression in human peripheral blood mononuclear cells. Definition of an IL-2-independent pathway of perforin induction in CD8+ T cells.
Perforin gene expression upon in vitro stimulation was studied at the mRNA level in normal human PBMC and in subpopulations… 
Highly Cited
1991
Highly Cited
1991
Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.
1990
1990
Transcriptional activation of the human cytotoxic serine protease gene CSP-B in T lymphocytes
The cytotoxic serine protease B (CSP-B) gene is activated during cytotoxic T-lymphocyte maturation. In this report, we… 
1990
1990
RNKP-1, a novel natural killer-associated serine protease gene cloned from RNK-16 cytotoxic lymphocytes.
From an RNK-16 lambda-gt11 library, we have isolated and sequenced a novel cDNA rat NK cell protease 1 (RNKP-1) that has… 
Highly Cited
1988
Highly Cited
1988
Characterization of three serine esterases isolated from human IL-2 activated killer cells.
Human peripheral blood mononuclear cells, activated for 14 to 20 days with 1000 U/ml rIL-2, develop strong cytotoxicity for NK… 
1988
1988
Organization of two genes encoding cytotoxic T lymphocyte-specific serine proteases CCPI and CCPII.
The genes encoding two recently described cytotoxic T cell proteases, CCPI and CCPII, have been isolated and sequenced. The… 
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