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GZMH gene

Known as: CGL2, CTSGL2, CTLA1 
National Institutes of Health

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GZMB gene

Papers overview

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Highly Cited
2015
Highly Cited
2015
Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes
Human ageing affects the immune system resulting in an overall decline in immunocompetence. Although all immune cells are… 
2013
2013
Identification of SERPINB1 As a Physiological Inhibitor of Human Granzyme H
The granzyme/perforin pathway is a major mechanism for cytotoxic lymphocytes to eliminate virus-infected and tumor cells. The… 
2012
2012
Structural Insights into the Substrate Specificity of Human Granzyme H: The Functional Roles of a Novel RKR Motif
Human granzyme H (GzmH) is constitutively expressed in human NK cells that have important roles in innate immune responses… 
2012
2012
Granzyme H of Cytotoxic Lymphocytes Is Required for Clearance of the Hepatitis B Virus through Cleavage of the Hepatitis B Virus X Protein
The granule exocytosis pathway of cytotoxic lymphocytes plays critical roles in eradication of intracellular viruses. However… 
Review
2008
Review
2008
Death by a thousand cuts: granzyme pathways of programmed cell death.
The granzymes are cell death-inducing enzymes, stored in the cytotoxic granules of cytotoxic T lymphocytes and natural killer… 
Highly Cited
2008
Highly Cited
2008
Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage.
2007
2007
cDNA cloning and in situ hybridization of a novel lysozyme in the Pacific oyster, Crassostrea gigas.
Highly Cited
2007
Highly Cited
2007
Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition
Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular… 
Highly Cited
2004
Highly Cited
2004
Discordant Regulation of Granzyme H and Granzyme B Expression in Human Lymphocytes*
We analyzed the expression of granzyme H in human blood leukocytes, using a novel monoclonal antibody raised against recombinant… 
Highly Cited
1991
Highly Cited
1991
Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.
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