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GZMH gene

Known as: CGL2, CTSGL2, CTLA1 
 
National Institutes of Health

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GZMB gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes
Human ageing affects the immune system resulting in an overall decline in immunocompetence. Although all immune cells are… Expand
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2013
2013
Identification of SERPINB1 As a Physiological Inhibitor of Human Granzyme H
The granzyme/perforin pathway is a major mechanism for cytotoxic lymphocytes to eliminate virus-infected and tumor cells. The… Expand
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2012
2012
Granzyme H of Cytotoxic Lymphocytes Is Required for Clearance of the Hepatitis B Virus through Cleavage of the Hepatitis B Virus X Protein
The granule exocytosis pathway of cytotoxic lymphocytes plays critical roles in eradication of intracellular viruses. However… Expand
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Highly Cited
2008
Highly Cited
2008
Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage.
Natural killer (NK) cells are the effectors of innate immunity to act as the first line of defense against viruses and tumors… Expand
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2007
2007
cDNA cloning and in situ hybridization of a novel lysozyme in the Pacific oyster, Crassostrea gigas.
A novel lysozyme cDNA from the Pacific oyster, Crassostrea gigas, was identified. This second lysozyme from the Pacific oyster… Expand
Highly Cited
2007
Highly Cited
2007
Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition
Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular… Expand
Highly Cited
2007
Highly Cited
2007
Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program.
Granzyme H (GzmH) belongs to a family of 5 human serine proteases that are expressed by cytotoxic immune effector cells. Although… Expand
Highly Cited
2004
Highly Cited
2004
Discordant Regulation of Granzyme H and Granzyme B Expression in Human Lymphocytes*
We analyzed the expression of granzyme H in human blood leukocytes, using a novel monoclonal antibody raised against recombinant… Expand
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1991
1991
Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.
We previously identified a cluster of hematopoietic serine protease genes on chromosome 14 at band q11.2. This cluster contains… Expand
1990
1990
Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C).
A human cDNA clone encoding a novel serine protease, cytotoxic serine protease-C(CSP-C), has been isolated from a cDNA library… Expand
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