• Publications
  • Influence
Role of Insulin Resistance in Human Disease
TLDR
The possibility is raised that resistance to insulin-stimulated glucose uptake and hyperinsulinemia are involved in the etiology and clinical course of three major related diseases— NIDDM, hypertension, and CAD. Expand
American College of Endocrinology position statement on the insulin resistance syndrome.
Banting lecture 1988. Role of insulin resistance in human disease.
  • G. Reaven
  • Medicine, Biology
  • Diabetes
  • 1 December 1988
TLDR
The development of hypertension in normal rats by an experimental manipulation known to induce insulin resistance and hyperinsulinemia provides further support for the view that the relationship between the three variables may be a causal one. Expand
A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.
TLDR
Fat-fed/STZ rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds. Expand
Use of Metabolic Markers To Identify Overweight Individuals Who Are Insulin Resistant
TLDR
The prevalence of insulin resistance is increased in patients with type 2 diabetes mellitus, essential hypertension, and CVD and that insulin resistance and compensatory hyperinsulinemia have been shown to be independent predictors of all 3 clinical syndromes. Expand
Hypertension and associated metabolic abnormalities--the role of insulin resistance and the sympathoadrenal system.
TLDR
It is hypothesized that the metabolic abnormalities linked to the hypertension by a pathophysiologic process that involves the sympathoadrenal system and exerts influence on blood pressure and complications in many patients. Expand
The metabolic syndrome: is this diagnosis necessary?
  • G. Reaven
  • Medicine
  • The American journal of clinical nutrition
  • 1 June 2006
TLDR
The argument that diagnosing the metabolic syndrome in a person has neither pedagogical nor clinical utility is developed, and it is suggested that the clinical emphasis should be on treating effectively any CVD risk factor that is present. Expand
Role of insulin resistance in human disease (syndrome X): an expanded definition.
  • G. Reaven
  • Medicine
  • Annual review of medicine
  • 1993
TLDR
It seems likely that the cluster of changes associated with resistance to insulin-mediated glucose uptake comprise a syndrome, which plays an important role in the etiology and clinical course of patients with non-insulin-dependent diabetes, high blood pressure, and coronary heart disease. Expand
Impaired Nitric Oxide Synthase Pathway in Diabetes Mellitus: Role of Asymmetric Dimethylarginine and Dimethylarginine Dimethylaminohydrolase
TLDR
A glucose-induced impairment of DDAH causes ADMA accumulation and may contribute to endothelial vasodilator dysfunction in DM. Expand
Fructose-induced insulin resistance and hypertension in rats.
TLDR
The addition of clonidine to the drinking water inhibited fructose-induced hypertension, but not the increase in plasma insulin or triglyceride concentration seen in fructose-fed rats, indicating that the metabolic changes associated with fructose- induced hypertension are unlikely to be secondary to an increase in sympathetic activity. Expand
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