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Improved Assessment of T-Cell Receptor (TCR) VB Repertoire in Clinical Specimens: Combination of TCR-CDR3 Spectratyping with Flow Cytometry-Based TCR VB Frequency Analysis
ABSTRACT Antigen-specific T-cell responses may be described by combining three categories: (i) the specificity and effector functions of a T-cell population, (ii) the quantity of T-cell responsesExpand
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Structure and evolutionary origin of the human granzyme H gene.
Among the molecules proposed to be involved in cytotoxic T lymphocyte (CTL), natural killer (NK) and lymphokine activated killer (LAK) cell-mediated lysis are the granzymes, a family of serineExpand
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Involvement of granzyme B and perforin gene expression in the lytic potential of human natural killer cells.
Natural killer (NK) cells (CD3- LGL) spontaneously kill K562 targets but are unable to kill Daudi cells in the absence of IL-2 stimulation. IL-4 is reported to prevent or inhibit the IL-2 drivenExpand
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A promoter element of the human serine esterase granzyme B gene controls specific transcription in activated T cells
The human granzyme B gene encodes a serine protease expressed specifically in cytoplasmic granules of cytotoxic T lymphocytes, released upon effector‐target cell interaction. Previous studies haveExpand
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Structural organization of the hCTLA-1 gene encoding human granzyme B.
Cytotoxic T lymphocytes (CTLs) and natural killer/lymphokine-activated cells produce granzymes, a family of serine esterase proteins located in cytoplasmic granules. These might be involved inExpand
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Perforin and granzyme B as markers for acute rejection in heart transplantation.
Histological analysis of endomyocardial biopsies (EMB) is regarded as the most satisfactory technique for monitoring crisis of rejection in heart transplanted patients. In this study, 42 biopsiesExpand
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In vitro activity of S 9788 on a multidrug-resistant leukemic cell line and on normal hematopoietic cells—reversal of multidrug resistance by sera from phase I-treated patients
The triazinoaminopiperidine derivative S 9788 is a new multidrug-resistance modulator that is currently being evaluated in phase I clinical trials. In this study, the reversal effect of S 9788 inExpand
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Proximity of the CTLA-1 serine esterase and Tcrα loci in mouse and man
The serine esterase CTLA-1 gene was shown by in situ hybridization to map to the D segment of mouse chromosome 14, the same localization as a member of the immunoglobulin super family, Tcrα. ToExpand
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Proximity of the CTLA-1 serine esterase and Tcr alpha loci in mouse and man.
The serine esterase CTLA-1 gene was shown by in situ hybridization to map to the D segment of mouse chromosome 14, the same localization as a member of the immunoglobulin superfamily, Tcr alpha. ToExpand
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