Granzymes

Known as: EC 3.4.21.-, Granzymes [Chemical/Ingredient], Granzyme 
A family of serine endopeptidases. Members of this family are stored in the granules of cytotoxic T cells. Upon release of the granules, these… (More)
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells are indispensable factors in the body's ongoing defence against… (More)
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Highly Cited
2007
Highly Cited
2007
Granzyme B is important for the ability of NK cells and CD8(+) T cells to kill their targets. However, we showed here that… (More)
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Highly Cited
2004
Highly Cited
2004
Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells use the perforin/granzyme pathway as a major mechanism to kill… (More)
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Review
2003
Review
2003
The granzyme/perforin pathway is a central pathway for lymphocyte-mediated killing in both the innate and adaptive immune systems… (More)
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Highly Cited
2003
Highly Cited
2003
Granzyme A (GzmA) induces a caspase-independent cell death pathway characterized by single-stranded DNA nicks and other features… (More)
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Highly Cited
2000
Highly Cited
2000
The essential upstream steps in granzyme B-mediated apoptosis remain undefined. Herein, we show that granzyme B triggers the… (More)
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Highly Cited
1999
Highly Cited
1999
Systemic autoimmune diseases are a genetically complex, heterogeneous group of disorders in which the immune system targets a… (More)
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Highly Cited
1999
Highly Cited
1999
Dipeptidyl peptidase I (DPPI) is a lysosomal cysteine protease that has been implicated in the processing of granzymes, which are… (More)
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Highly Cited
1994
Highly Cited
1994
We have generated H-2b mice with a homozygous null mutation in the granzyme (gzm) B gene. Gzm B is a neutral serine protease with… (More)
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Highly Cited
1991
Highly Cited
1991
Cytotoxic T lymphocytes (CTL) contain granules that are exocytosed during specific interaction with target cells (TC). In this… (More)
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