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Granzymes

Known as: EC 3.4.21.-, Granzymes [Chemical/Ingredient], Granzyme 
A family of serine endopeptidases. Members of this family are stored in the granules of cytotoxic T cells. Upon release of the granules, these… 
National Institutes of Health

Related topics

Related topics

22 relations
Cellular ImmunityGZMA protein, humanGZMB protein, humanIn Blood

Broader (1)

Cytotoxin

Narrower (7)

GZMH protein, humanGranzyme CGranzyme KGzmc protein, mouse

Papers overview

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Highly Cited
2011
Highly Cited
2011
Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function…
Review
2004
Review
2004
Advances in pre- and posttransplant immunologic testing in kidney transplantation.
Highly Cited
1998
Highly Cited
1998
Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide
Highly Cited
1997
Highly Cited
1997
Enteropathy‐associated T‐cell lymphomas have a cytotoxic T‐cell phenotype
Enteropathy‐associated T‐cell lymphoma (EATCL) is a rare complication of coeliac disease. We investigated whether EATCLs are the… 
Highly Cited
1994
Highly Cited
1994
Cytotoxic lymphocyte granzymes trigger a target cell internal disintegration pathway leading to cytolysis and DNA breakdown.
Two approaches have been used to assess the hypothesis that granzymes secreted by cytotoxic lymphocytes act within the target… 
Highly Cited
1993
Highly Cited
1993
A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14.
Highly Cited
1993
Highly Cited
1993
The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression.
Genes encoding T-cell-receptor alpha/delta chains, neutrophil cathepsin G, and lymphocyte CGL/granzymes are closely linked on… 
Highly Cited
1991
Highly Cited
1991
Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase.
Highly Cited
1991
Highly Cited
1991
Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme…
Mouse gut intraepithelial lymphocytes (IEL), whether thymodependent (CD4+ or CD8 alpha/beta +; TCR-alpha/beta +) or… 
Highly Cited
1989
Highly Cited
1989
Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A
The rapid breakdown of target cell DNA during CTL-mediated lysis has been difficult to explain by the granule exocytosis model of… 
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