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Granzymes

Known as: EC 3.4.21.-, Granzymes [Chemical/Ingredient], Granzyme 
A family of serine endopeptidases. Members of this family are stored in the granules of cytotoxic T cells. Upon release of the granules, these… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Effective adoptive T cell therapy (ACT) comprises the killing of cancer cells through the therapeutic use of transferred T cells… Expand
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Highly Cited
2007
Highly Cited
2007
Granzyme B is important for the ability of NK cells and CD8(+) T cells to kill their targets. However, we showed here that… Expand
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Highly Cited
2005
Highly Cited
2005
CD4+CD25+ regulatory T cells (Treg) are potent immunosuppressive cells that are pivotal in the regulation of peripheral tolerance… Expand
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Highly Cited
2004
Highly Cited
2004
Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells use the perforin/granzyme pathway as a major mechanism to kill… Expand
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Review
2002
Review
2002
Cytotoxic T lymphocytes (CTLs) provide potent defences against virus infection and intracellular pathogens. However, CTLs have a… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Acute rejection is a serious and frequent complication of renal transplantation, and its diagnosis is contingent on… Expand
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Highly Cited
1997
Highly Cited
1997
There is compelling evidence that members of the caspase (interleukin-1β converting enzyme/CED-3) family of cysteine proteases… Expand
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Highly Cited
1995
Highly Cited
1995
CYTOTOXIC T lymphocyte (CTL)-mediated cytotoxicity represents the body's major defence against virus-infected and tumorigenic… Expand
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Highly Cited
1994
Highly Cited
1994
We have generated H-2b mice with a homozygous null mutation in the granzyme (gzm) B gene. Gzm B is a neutral serine protease with… Expand
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Highly Cited
1991
Highly Cited
1991
Cytotoxic T lymphocytes (CTL) contain granules that are exocytosed during specific interaction with target cells (TC). In this… Expand
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