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Missing heritability and strategies for finding the underlying causes of complex disease
Although recent genome-wide studies have provided valuable insights into the genetic basis of human disease, they have explained relatively little of the heritability of most complex traits, and theExpand
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Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function
Coat colors in the chestnut horse, the yellow Labrador retriever, the red fox, and one type of yellow mouse are due to recessive alleles at the extension locus. Similarly, dominant alleles at thisExpand
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Lengths of chromosomal segments conserved since divergence of man and mouse.
  • J. Nadeau, B. Taylor
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 February 1984
Linkage relationships of homologous loci in man and mouse were used to estimate the mean length of autosomal segments conserved during evolution. Comparison of the locations of greater than 83Expand
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Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos.
We have isolated two mouse genes, Mox-1 and Mox-2 that, by sequence, genomic structure and expression pattern, define a novel homeobox gene family probably involved in mesodermal regionalization andExpand
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Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice
Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes.Expand
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The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours
In mice, the Ter mutation causes primordial germ cell (PGC) loss in all genetic backgrounds. Ter is also a potent modifier of spontaneous testicular germ cell tumour (TGCT) susceptibility in the 129Expand
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Oriented Asymmetric Divisions That Generate the Stomatal Spacing Pattern in Arabidopsis Are Disrupted by the too many mouths Mutation
Wild-type stomata are spaced by intervening cells, a pattern disrupted in the Arabidopsis mutant too many mouths (tmm). To determine the mechanism of wild-type spacing and how tmm results in patternExpand
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Finding Genes That Underlie Complex Traits
Phenotypic variation among organisms is central to evolutionary adaptations underlying natural and artificial selection, and also determines individual susceptibility to common diseases. These typesExpand
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Analysing complex genetic traits with chromosome substitution strains
Many valuable animal models of human disease are known and new models are continually being generated in existing inbred strains1,2. Some disease models are simple mendelian traits, but most have aExpand
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Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
Type 1 diabetes or insulin-dependent diabetes mellitus (IDDM) is due to autoimmune destruction of pancreatic β-cells. Genetic susceptibility to IDDM is encoded by several loci, one of which (IDDM2)Expand
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