Skip to search formSkip to main contentSkip to account menu
A new member of the immunoglobulin superfamily—CTLA-4
TLDR
CTLA-4 is mainly expressed in activated lymphocytes and is coinduced with T-cell-mediated cytotoxicity in inducible models of this process and could encode a 223-amino-acid protein clearly belonging to the immunoglobulin superfamily.
View on Nature
A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion
TLDR
It is suggested that three proteins that form a distinct branch of the Rho family control rearrangements of the actin cytoskeleton and changes in cell adhesion, including Rnd1, which has a low affinity for GDP and spontaneously exchanges nucleotide rapidly in a physiological buffer.
View PDF
A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment.
View on PubMed
Family of Ebf/Olf‐1‐related genes potentially involved in neuronal differentiation and regional specification in the central nervous system
TLDR
A detailed analysis of the expression of each of the three Ebf genes in the developing central nervous system revealed partially overlapping patterns with two salient features, which suggest that Eb f genes may be involved in the control of neuronal differentiation in the CNS and in enforcing regional diversity in populations of post‐mitotic forebrain neurons.
View on Wiley
A novel putative receptor protein tyrosine kinase of the met family.
By successive screenings of cDNA libraries prepared from human tumours and from human foreskin keratinocytes, we have isolated overlapping cDNAs coding for a novel protein which we call Ron, with…
View on PubMed
CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene.
TLDR
CTLA-8 may belong to the growing set of virus-captured functionally important cellular genes related to the immune system or to cell death and cell survival, and is discussed in the context of other genes of this herpesvirus homologous to known immunologically active molecules.
View on PubMed
Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain
View on Elsevier
Early expression of AMH in chicken embryonic gonads precedes testicular SOX9 expression
TLDR
Results do not support the hypothesis that SOX9 could trigger the expression of testicular AMH in the chick but does not exclude a later role in testis development, and potential SOX response elements were found in the AMH promoter.
View on Wiley
CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.
TLDR
CD28 and CTLA-4 were found to be strikingly similar in most respects, in terms of structure, sequence, expression, and gene location, furthermore in two species, strongly suggesting that their genes are the direct products of a duplication event and raising the possibility of functional homologies between the corresponding proteins.
View on PubMed
A Novel, Secreted Form of Human ADAM 12 (Meltrin α) Provokes Myogenesis in Vivo *
TLDR
A novel, secreted form of human ADAM 12 (meltrin α), designatedADAM 12-S (S for short), and a larger, membrane-bound form designated ADam 12-L (L for long form) are described, which have potential applications in the development of muscle-directed gene and cell therapies.
View on Publisher
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License