• Publications
  • Influence
The Fas death factor
Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereasExpand
  • 4,210
  • 93
Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family
The Fas antigen (Fas) belongs to the tumor necrosis factor (TNF)/nerve growth factor receptor family, and it mediates apoptosis. Using a soluble form of mouse Fas, prepared by fusion with humanExpand
  • 2,540
  • 48
Cell death by necrosis: towards a molecular definition.
Necrosis has been defined as a type of cell death that lacks the features of apoptosis and autophagy, and is usually considered to be uncontrolled. Recent research suggests, however, that itsExpand
  • 951
  • 43
  • PDF
A new member of the immunoglobulin superfamily—CTLA-4
The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains1,2.Expand
  • 938
  • 34
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Different types of cell death are often defined by morphological criteria, without a clear reference to precise biochemical mechanisms. The Nomenclature Committee on Cell Death (NCCD) proposesExpand
  • 2,503
  • 29
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity.
Two molecular mechanisms of T cell-mediated cytotoxicity, one perforin-based, the other Fas-based, have been demonstrated. To determine the extent of their contribution to T cell-mediatedExpand
  • 1,649
  • 21
Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity
Mechanisms of T cell-mediated cytotoxicity remain poorly defined at the molecular level. To investigate some of these mechanisms, we used as target cells, on the one hand, thymocytes from lpr and gldExpand
  • 845
  • 21
  • PDF
CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene.
To detect novel molecules involved in immune functions, a subtracted cDNA library between closely related murine lymphoid cells was prepared using improved technology. Differential screening of thisExpand
  • 676
  • 17
CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.
CD28, initially detected on human T lymphocytes with the help of antibodies, and CTLA-4, obtained by reverse genetics through its preferential expression in mouse activated T cells, are both single-VExpand
  • 411
  • 15
Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester
Although it has been proposed that the activation of T lymphocytes is mediated by an early rise in cytosolic calcium concentration1–4, it has not been possible to mimic antigen- or mitogen-inducedExpand
  • 675
  • 12