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GRM2 wt Allele

Known as: Glutamate Receptor, Metabotropic 2 wt Allele, GLUR2, GPRC1B 
Human GRM2 wild-type allele is located in the vicinity of 3p21.2 and is approximately 12 kb in length. This allele, which encodes metabotropic… 
National Institutes of Health

Related topics

Related topics

6 relations
3p21.2G Protein-Coupled Receptor SignalingLigand BindingReceptor Signaling

Papers overview

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Highly Cited
2015
Highly Cited
2015
Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity
Significance Chronic stress alters the hippocampal responses to familiar and novel stressors, behaviorally, physiologically, and… 
Highly Cited
2011
Highly Cited
2011
Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists
Highly Cited
2008
Highly Cited
2008
The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity
RationaleGroup II metabotropic glutamate receptors (mGluRs) comprise the mGluR2 and mGluR3 subtypes, the activation and… 
Highly Cited
2007
Highly Cited
2007
The Use of Knock-Out Mice Unravels Distinct Roles for mGlu2 and mGlu3 Metabotropic Glutamate Receptors in Mechanisms of Neurodegeneration/Neuroprotection
Dual metabotropic glutamate 2/3 (mGlu2/3) receptor agonists have been examined with success in the clinic with positive proof of… 
Review
2005
Review
2005
Metabotropic glutamate receptors as novel targets for anxiety and stress disorders
Anxiety and stress disorders are the most commonly occurring of all mental illnesses, and current treatments are less than… 
Review
2003
Review
2003
LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress
Metabotropic glutamate (mGlu) receptors, which include mGlu1-8 receptors, are a heterogeneous family of G-protein coupled… 
Highly Cited
2003
Highly Cited
2003
Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3…
This report describes recently discovered novel allosteric modulators of metabotropic glutamate2 (mGlu2) receptors. These… 
Highly Cited
1999
Highly Cited
1999
Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two…
As part of our ongoing research program aimed at the identification of highly potent, selective, and systemically active agonists… 
Review
1999
Review
1999
Glutamate receptors and transporters in genetic and acquired models of epilepsy
Highly Cited
1994
Highly Cited
1994
Rapid Communication Chronic Ingestion of Ethanol Up‐Regulates NMDAR1 Receptor Subunit Immunoreactivity in Rat Hippocampus
We examined the effects of chronic ethanol exposure on the levels of N‐methyl‐D‐aspartate receptor subunit 1 (NMDAR1) protein, an… 
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