The neuropathology of schizophrenia. A critical review of the data and their interpretation.
- Paul J. Harrison
- Psychology, BiologyBrain : a journal of neurology
- 1 April 1999
Functional imaging data indicate that the pathophysiology of schizophrenia reflects aberrant activity in, and integration of, the components of distributed circuits involving the prefrontal cortex, hippocampus and certain subcortical structures.
Catechol-o-Methyltransferase, Cognition, and Psychosis: Val158Met and Beyond
Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
The author has identified an error on the sixth page of the above paper that should simply read: ‘COMT has significantly lower enzyme activity than net-COMT’.
Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis
6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records
The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications
- Paul J. Harrison
- Psychology, BiologyPsychopharmacology
- 6 March 2004
The results are together suggestive of an altered synaptic circuitry or “wiring” within the hippocampus and its extrinsic connections, especially with the prefrontal cortex, which plausibly represent the anatomical component of the aberrant functional connectivity that underlies schizophrenia.
Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease.
- A. Law, B. Lipska, D. Weinberger
- BiologyProceedings of the National Academy of Sciences…
- 25 April 2006
Bioinformatic promoter analyses indicate that variation in isoform expression as a molecular mechanism for the genetic association of NRG1 with schizophrenia implicate variation inisoform expression in patients and controls.
Guidelines for the laboratory investigation of heritable disorders of platelet function
The objective of this guideline is to provide healthcare professionals with clear guidance on platelet function testing in patients with suspected bleeding disorders and in all cases individual patient circumstances may dictate an alternative approach.