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Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.
TLDR
Quinoxalinediones have been found to be potent and competitive antagonists at non-NMDA glutamate receptors and will be useful in the determination of the structure-activity relations of quisqualate and kainate receptors and the role of such receptors in synaptic transmission in the mammalian brain.
A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission
TLDR
The effects of a potent and selective agonist and a selective antagonist are used to show that kainate receptors, comprised of or containing GluR5 subunits, regulate synaptic inhibition in the hippocampus, an action that could contribute to the epileptogenic effects of kainates.
Kainate receptors are involved in synaptic plasticity
TLDR
It is found that LY382884 is a selective antagonist at neuronal kainate receptors containing the GluR5 subunit, which has no effect on long-term potentiation (LTP) that is dependent onNMDA receptors but prevents the induction of mossy fibre LTP, which is independent of NMDA receptors.
The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate
TLDR
The results suggest that reduction of synaptic excitation mediated via NMA receptors contributes to the anaesthetic/analgesic properties of these two dissociative anaesthetics.
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