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Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain.
The inhibitory glycine receptor (GlyR) is a ligand‐gated ion channel which mediates post‐synaptic inhibition in spinal cord and other regions of the vertebrate central nervous system. Previous… Expand
Neuroligin 2 Drives Postsynaptic Assembly at Perisomatic Inhibitory Synapses through Gephyrin and Collybistin
- Alexandros Poulopoulos, G. Aramuni, +14 authors F. Varoqueaux
- Biology, Medicine
- 10 September 2009
In the mammalian CNS, each neuron typically receives thousands of synaptic inputs from diverse classes of neurons. Synaptic transmission to the postsynaptic neuron relies on localized and… Expand
GlyR α3: An Essential Target for Spinal PGE2-Mediated Inflammatory Pain Sensitization
Prostaglandin E2 (PGE2) is a crucial mediator of inflammatory pain sensitization. Here, we demonstrate that inhibition of a specific glycine receptor subtype (GlyR α3) by PGE2-induced receptor… Expand
Deletion of the Mouse Glycine Transporter 2 Results in a Hyperekplexia Phenotype and Postnatal Lethality
The glycine transporter subtype 2 (GlyT2) is localized in the axon terminals of glycinergic neurons. Mice deficient in GlyT2 are normal at birth but during the second postnatal week develop a lethal… Expand
Molecular Determinants of Agonist Discrimination by NMDA Receptor Subunits: Analysis of the Glutamate Binding Site on the NR2B Subunit
NMDA receptors require both L-glutamate and the coagonist glycine for efficient channel activation. The glycine binding site of these heteromeric receptor proteins is formed by regions of the NMDAR1… Expand
Loss of Postsynaptic GABAA Receptor Clustering in Gephyrin-Deficient Mice
- M. Kneussel, J. Brandstätter, B. Laube, S. Stahl, U. Müller, H. Betz
- Chemistry, Medicine
- The Journal of Neuroscience
- 1 November 1999
The tubulin-binding protein gephyrin, which anchors the inhibitory glycine receptor (GlyR) at postsynaptic sites, decorates GABAergic postsynaptic membranes in various brain regions, and postsynaptic… Expand
Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin
The formation of postsynaptic GABAA and glycine receptor clusters requires the receptor-associated peripheral membrane protein gephyrin. Here we describe two splice variants of a novel… Expand
The β Subunit Determines the Ligand Binding Properties of Synaptic Glycine Receptors
Inhibitory glycine receptors (GlyRs) regulate motor coordination and sensory signal processing in spinal cord and other brain regions. GlyRs are pentameric proteins composed of membrane-spanning… Expand
Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity.
Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin. Molecular cloning revealed the similarity of gephyrin to prokaryotic and invertebrate proteins… Expand
Glycine transporters: essential regulators of neurotransmission.
- V. Eulenburg, W. Armsen, H. Betz, J. Gomeza
- Biology, Medicine
- Trends in biochemical sciences
- 1 June 2005
Glycine has important neurotransmitter functions at inhibitory and excitatory synapses in the vertebrate central nervous system. The effective synaptic concentrations of glycine are regulated by… Expand