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GRK5 gene

Known as: G protein-coupled receptor kinase 5, G Protein-Coupled Receptor Kinase 5 Gene, GPRK5 
This gene plays a role in signal transduction and the regulation of polymorphonuclear leukocyte motility.
National Institutes of Health

Related topics

Related topics

7 relations
G Protein-Coupled Receptor SignalingG-protein coupled receptor kinase activityG-protein-coupled receptor kinase 5GRK5 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
G Protein-Coupled Receptor Kinases
The importance of G protein-coupled receptor (GPCR) kinases (GRKs) as regulators of GPCR signaling has been widely recognized. In… 
Highly Cited
2009
Highly Cited
2009
Clinical and genetic modifiers of long-term survival in heart failure.
Highly Cited
2004
Highly Cited
2004
Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies…
Agonist-stimulated desensitization of the beta2-adrenergic receptor (beta2AR) is caused by both a potent cAMP-dependent protein… 
Highly Cited
2003
Highly Cited
2003
G-protein-coupled Receptor (GPCR) Kinase Phosphorylation and β-Arrestin Recruitment Regulate the Constitutive Signaling Activity of the Human Cytomegalovirus US28 GPCR*
Phosphorylation of G-protein-coupled receptors (GPCRs) by GRKs and subsequent recruitment of β-arrestins to agonist-occupied… 
Highly Cited
2002
Highly Cited
2002
Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.
Lymphocyte chemotaxis is a complex process by which cells move within tissues and across barriers such as vascular endothelium… 
Highly Cited
2000
Highly Cited
2000
G Protein-coupled Receptor Kinase-mediated Desensitization of Metabotropic Glutamate Receptor 1A Protects against Cell Death*
Metabotropic glutamate receptors (mGluRs) constitute a unique subclass of G protein-coupled receptors (GPCRs) that bear little… 
Highly Cited
1998
Highly Cited
1998
Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy.
Using Xenopus laevis oocytes coexpressing mammalian mu-opioid receptors (MORs), beta-adrenergic receptor kinase 2 (beta-ARK2… 
Highly Cited
1996
Highly Cited
1996
Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor*
Rapid desensitization of G protein-coupled receptors is mediated, at least in part, by their phosphorylation by the G protein… 
Highly Cited
1996
Highly Cited
1996
Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases (*)
The role of G protein-coupled receptor kinases (GRKs) in the regulation of dopamine D1A receptor responsiveness is poorly… 
Highly Cited
1995
Highly Cited
1995
Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase.
Persistent stimulation of the beta 1-adrenergic receptor (beta 1AR) engenders, within minutes, diminished responsiveness of the… 
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