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Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
The identification of an orphan human G-protein-coupled receptor homologous to rat GPR14 and expressed predominantly in cardiovascular tissue, which functions as a U-II receptor, the most potent mammalian vasoconstrictor identified so far. Expand
A G Protein-coupled Receptor for UDP-glucose*
It is shown that UDP-glucose, and some closely related molecules, potently activate the orphan G protein-coupled receptor KIAA0001 heterologously expressed in yeast or mammalian cells, suggesting that some sugar-nucleotides may serve important physiological roles as extracellular signaling molecules in addition to their familiar role in intermediary metabolism. Expand
The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects
The purpose of the present study was to test the hypothesis that human recombinant GPR55 is activated by atypical cannabinoids and mediates vasodilator responses to these agents. Expand
A cDNA Encoding the Calcitonin Gene-related Peptide Type 1 Receptor (*)
  • N. Aiyar, K. Rand, +4 authors Y. Li
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 10 May 1996
The cloning of a complementary DNA (cDNA) encoding a human CGRP receptor, which shares significant peptide sequence homology with the human calcitonin receptor, a member of the G-protein-coupled receptor superfamily, is reported here. Expand
Differential vasoconstrictor activity of human urotensin‐II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey
Interestingly, significant differences in reproducibility and vasoconstrictor efficacy were seen in tissue from pigs and New World primates (vessels which responded to noradrenaline, phenylephrine, KCl or ET‐1 consistently), supporting the hypothesis that U‐II influences the physiological regulation of mammalian cardiovascular function. Expand
Novel Function for Receptor Activity-modifying Proteins (RAMPs) in Post-endocytic Receptor Trafficking*♦
Results indicate a novel function for RAMP3 in the post-endocytic sorting of the AM-R and suggest a broader regulatory role for RAMPs in receptor trafficking. Expand
Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats
These data provide further evidence for widespread roles for NmU and its receptors in the brain by mapping NMU1R and NMU2R mRNA and measuring the behavioural, endocrine, neurochemical and c-fos response to intracerebroventricular (i.c.v.) Nm U. Expand
Molecular and pharmacological characterization of genes encoding urotensin‐II peptides and their cognate G‐protein‐coupled receptors from the mouse and monkey
Urotensin‐II (U‐II) and its receptor (UT) represent novel therapeutic targets for management of a variety of cardiovascular diseases. To test such hypothesis, it will be necessary to developExpand
Urotensin-II-mediated cardiomyocyte hypertrophy: effect of receptor antagonism and role of inflammatory mediators
  • D. Johns, Z. Ao, +6 authors S. Douglas
  • Biology, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 30 September 2004
Results indicate that U-II might play a role in cardiac remodeling associated with CHF by stimulation of cardiomyocyte hypertrophy via UT, and through upregulation of inflammatory cytokines, and may represent a novel therapeutic target for the clinical management of heart failure. Expand
Cloning and characterization of a human angiotensin II type 1 receptor.
Southern and Northern blot analyses indicated that the cloned receptor is represented as a single copy in the human genome and is expressed in many tissues of different histogenic origin with the exception of brain, where mRNA transcripts were barely detectable. Expand