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Role of Nitric Oxide in Central Sympathetic Outflow
The gaseous molecule nitric oxide (NO) plays an important role in cardiovascular homeostasis. It plays this role by its action on both the central and peripheral autonomic nervous systems. In thisExpand
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Interaction between glutamate and GABA systems in the integration of sympathetic outflow by the paraventricular nucleus of the hypothalamus.
The paraventricular nucleus (PVN) of the hypothalamus is a central site known to modulate sympathetic outflow. Excitatory and inhibitory neurotransmitters within the PVN dictate final outflow. TheExpand
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Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: role of GABA.
  • K. Zhang, K. Patel
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 September 1998
Both nitric oxide (NO) and GABA are known to provide inhibitory inputs to the paraventricular nucleus (PVN) of the hypothalamus and are involved in the control of sympathetic outflow. The purpose ofExpand
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Alteration of NMDA NR1 Receptors Within the Paraventricular Nucleus of Hypothalamus in Rats With Heart Failure
Abstract— One of the pathophysiological characteristics of chronic heart failure (HF) is elevated sympathetic drive, which is a major factor contributing to the morbidity and mortality of HF. ResentExpand
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Nitric oxide within the paraventricular nucleus mediates changes in renal sympathetic nerve activity.
The paraventricular nucleus (PVN) of the hypothalamus is known to be involved in the control of sympathetic outflow. The goal of the present study was to examine the role of nitric oxide within theExpand
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Diabetes increases formation of advanced glycation end products on Sarco(endo)plasmic reticulum Ca2+-ATPase.
Prolongation of relaxation is a hallmark of diabetic cardiomyopathy. Most studies attribute this defect to decreases in sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a) expression andExpand
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Neural regulation of sympathetic nerve activity in heart failure.
One of the hallmarks of chronic congestive heart failure is an increase in sympathetic tone to the peripheral circulation and to the heart. A correlation between plasma norepinephrine and theExpand
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Reduced endogenous GABA-mediated inhibition in the PVN on renal nerve discharge in rats with heart failure.
One characteristic of heart failure (HF) is increased sympathetic activation. The paraventricular nucleus (PVN) of the hypothalamus (involved in control of sympathetic outflow) has been shown to haveExpand
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Role of Paraventricular Nucleus in Mediating Sympathetic Outflow in Heart Failure
  • K. Patel
  • Medicine
  • Heart Failure Reviews
  • 1 March 2000
A number of neurohumoral processes are activated in heart failure, including an increase in the plasma concentration of norepinephrine. Few studies have been performed to examine the role of theExpand
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Angiotensin-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide.
The paraventricular nucleus (PVN) of the hypothalamus is known to be an important site of integration in the central nervous system for sympathetic outflow. ANG II and nitric oxide (NO) play anExpand
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