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Role of Nitric Oxide in Central Sympathetic Outflow
The gaseous molecule nitric oxide (NO) plays an important role in cardiovascular homeostasis. It plays this role by its action on both the central and peripheral autonomic nervous systems. In this… Expand
Interaction between glutamate and GABA systems in the integration of sympathetic outflow by the paraventricular nucleus of the hypothalamus.
- Yi-Fan Li, Keshia Jackson, J. Stern, Brandon Rabeler, K. Patel
- Chemistry, Medicine
- American journal of physiology. Heart and…
- 1 December 2006
The paraventricular nucleus (PVN) of the hypothalamus is a central site known to modulate sympathetic outflow. Excitatory and inhibitory neurotransmitters within the PVN dictate final outflow. The… Expand
Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: role of GABA.
Both nitric oxide (NO) and GABA are known to provide inhibitory inputs to the paraventricular nucleus (PVN) of the hypothalamus and are involved in the control of sympathetic outflow. The purpose of… Expand
Alteration of NMDA NR1 Receptors Within the Paraventricular Nucleus of Hypothalamus in Rats With Heart Failure
Abstract— One of the pathophysiological characteristics of chronic heart failure (HF) is elevated sympathetic drive, which is a major factor contributing to the morbidity and mortality of HF. Resent… Expand
Nitric oxide within the paraventricular nucleus mediates changes in renal sympathetic nerve activity.
The paraventricular nucleus (PVN) of the hypothalamus is known to be involved in the control of sympathetic outflow. The goal of the present study was to examine the role of nitric oxide within the… Expand
Diabetes increases formation of advanced glycation end products on Sarco(endo)plasmic reticulum Ca2+-ATPase.
Prolongation of relaxation is a hallmark of diabetic cardiomyopathy. Most studies attribute this defect to decreases in sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a) expression and… Expand
Neural regulation of sympathetic nerve activity in heart failure.
- I. Zucker, W. Wang, M. Brändle, H. D. Schultz, K. Patel
- Progress in cardiovascular diseases
- 1 May 1995
One of the hallmarks of chronic congestive heart failure is an increase in sympathetic tone to the peripheral circulation and to the heart. A correlation between plasma norepinephrine and the… Expand
Reduced endogenous GABA-mediated inhibition in the PVN on renal nerve discharge in rats with heart failure.
One characteristic of heart failure (HF) is increased sympathetic activation. The paraventricular nucleus (PVN) of the hypothalamus (involved in control of sympathetic outflow) has been shown to have… Expand
Role of Paraventricular Nucleus in Mediating Sympathetic Outflow in Heart Failure
- K. Patel
- Heart Failure Reviews
- 1 March 2000
A number of neurohumoral processes are activated in heart failure, including an increase in the plasma concentration of norepinephrine. Few studies have been performed to examine the role of the… Expand
Angiotensin-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide.
- Yi-fan Li, W. Wang, W. Mayhan, K. Patel
- American journal of physiology. Regulatory…
- 1 December 2001
The paraventricular nucleus (PVN) of the hypothalamus is known to be an important site of integration in the central nervous system for sympathetic outflow. ANG II and nitric oxide (NO) play an… Expand