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Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor Published, JLR Papers in Press, August 1, 2004. DOI 10.1194/jlr.M400257-JLR200
Cell-based studies indicate that DMHCA enhances cholesterol efflux in macrophages and suggest a mechanism whereby this selective modulator can potentially inhibit cholesterol accumulation, and may have application to the study and treatment of atherosclerosis. Expand
Reversal of postischemic acute renal failure with a selective endothelinA receptor antagonist in the rat.
Results indicate that in the rat, the ETA receptor subtype mediates tubular epithelial function, and it plays a significant role in the pathogenesis of ischemia-induced ARF, an effect of possible therapeutic significance. Expand
Endothelin B receptor modulates inflammatory pain and cutaneous inflammation.
The results implicate the ET(B) receptor in mediation of inflammatory pain and cutaneous inflammatory responses in mice. Expand
Molecular characterization and regulation of the human endothelin receptors.
Northern analysis indicated that the two ETRs are differentially expressed in many tissues, and availability of cDNA clones for ETR subtypes can open avenues for future analysis of their role in pathophysiology of various diseases. Expand
Endothelin inhibits vasopressin action in rat inner medullary collecting duct via the ETB receptor.
Results from functional, biochemical and binding studies suggest that the ETB receptor is the ET receptor subtype that inhibits AVP action in the rat IMCD. Expand
Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors.
Results suggest the involvement of GRK6 in CGRP-mediated desensitization in HEK-293 cells, as well as the potential GRK specificity, which was tested against several G protein-coupled receptor kinases. Expand
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse[S]
Way-252623 (LXR-623) is a highly selective and orally bioavailable synthetic modulator of LXR, which demonstrated efficacy for reducing lesion progression in the murine LDLR−/− atherosclerosis model with no associated increase in hepatic lipogenesis either in this model or Syrian hamsters. Expand
Nonpeptide endothelin receptor antagonists. II. Pharmacological characterization of SB 209670.
The pharmacological characterization of SB 209670, a highly potent nonpeptide endothelin ETA/ETB receptor antagonist was performed. SB 209670 produced concentration-dependent, parallel rightwardExpand
Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells
The present study along with earlier studies strongly support the role of RAMPs in the functional expression of specific CRLRs. Expand
Adrenomedullin decreases extracellular signal-regulated kinase activity through an increase in protein phosphatase-2A activity in mesangial cells.
The mechanism of adrenomedullin-induced decrease in ERK activity in rat mesangial cells is at least in part mediated by an increase in PP2A activity, and the role of protein phosphatase 2A (PP2A) in the decrease is identified. Expand